[The agreed experts' position of the Eurasian Association of Therapists on tactics of management of patients with comorbid pathology infected with SARS-Cov-2].

The agreement of experts of the Eurasian Association of Therapists (EAT) discusses pathogenesis and treatment of COVID-19. Modern data on the characteristics of cardiovascular, kidney, respiratory damage in SARS-infected CoV-2 are presented. The tactics of managing patients initially having cardiovascular diseases, diabetes mellitus, chronic obstructive pulmonary disease, bronchial asthma, chronic kidney disease are discussed in detail.

[Age features of treatment of idiopathic membranoproliferative glomerulonephritis].

The aim of the study was to investigate the effectiveness of long application of the combined therapy by cytostatics and steroid hormones for patients with morphologically proved membranoproliferative glomerulonephritis depending on age. 51 patients younger 60 years and 27 patients older 60 years were investigated. Patients received therapy by steroid hormones and cytostatics within one year.

[Combined therapy of membranoproliferative glomerulonephritis in older patients].

The aim of the study was to investigate the effectiveness of combined long-term therapy by cytostatics and steroid hormones in older patients with membranoproliferative glomerulonephritis to halt renal failure progression. 27 patients older than 60 years with morphologically proved membranoproliferative glomerulonephritis have been treated. Nephrosclerosis was detected in 40% of studied patients according to results of kidney biopsies.

Effect of spironolactone on hypertrophy of left ventricular myocardium in wistar rats with experimental uremia.

Chronic renal failure was modeled in rats by partial nephrectomy. Blood pressure, heart rate, concentrations of aldosterone, urea, creatinine, electrolytes, and protein, index of hypertrophy of visceral organs, and 24-h diuresis were evaluated. In rats treated with spironolactone, the index of myocardial hypertrophy did not considerably differ from that in sham-operated animals, whereas in untreated rats the test parameters considerably differ from the control.

[The characteristics of left ventricular myocardial remodeling in patients with chronic renal disease, and the effects of spironolactone therapy].

The work reflects modern concepts of the pathogenesis of myocardial and vascular remodelling in a chronic renal disease. Types of changes in left ventricular geometry and the condition of the diastolic function in patients at pre-dialysis stage of a chronic renal disease and patients on program hemodialysis. Dynamic changes in left ventricular parameters under the influence of therapy with spironolactone, an aldosterone receptor blocker, are described.

[Effect of protein load on kidney functions in patients with chronic glomerulonephritis].

Aim: To study changes in renal function in response to protein loads in patients with chronic glomerulonephritis (CGN) who have normal renal function and initial uremia.

Material And Methods: 63 CGN patients were divided into two groups: 40 patients of group 1 (17 males, 23 females, age 16-53 years, plasma creatinine-Pcr < 0.132 mmol/l); 23 patients of group 2 (10 males, 13 females, age 18-57 years, Pcr > 0.

[The effect of urea on the course of experimental uremia in rats with a subtotal nephrectomy].

The important role of increasing plasma urea levels in renal failure progression was shown in Wistar rats with experimental uremia induced by subtotal nephrectomy. Renal structural lesions and dysfunction were the same as in rats fed a high-protein diet and in those on a low-protein diet supplemented with urea. The changes were much less in the control group of rats fed a low-protein diet alone.

[The reaction of the kidneys and acid-base and osmotic homeostasis to moderate physical exertion in patients with chronic pyelonephritis in the pre-azotemia period].

Bicycle ergometry (BE) up to submaximal heart rate provoked moderate metabolic acidosis in 52 patients with chronic pyelonephritis (CP) in preuremic stage. Similar changes in acid-base balance following BE were noted in 14 patients with chronic glomerulonephritis (CGN). BE in CP promoted the reduction in diuresis and fraction water excretion, elevation of creatinine concentration in the urine and its concentration index in the absence of alterations in sodium and osmotic homeostasis.

[The effect of the angiotensin-converting enzyme inhibitor enalapril on the rates of progression of chronic kidney failure in patients with different degrees of functional kidney disorders].

By a reciprocal of creatininemia the rate of chronic renal failure progression (CRF) was assessed in 14 patients with nephropathy on enalapril treatment. The day dose ranged from 2.5 to 15 mg.

[The role of disorders in the tubular transport of water and osmotically active substances in the progression of chronic kidney failure].

Lithium clearance served the criterion for measuring proximal and distal tubular transport of water, sodium and osmotically active substances (OAS) in 41 patients with chronic renal failure (CRF) of various degree. Distal reabsorption of water and sodium occurs early in CRF. In moderate disease the authors observed a drastic rise in distal excreted fraction of OAS which surpassed that of sodium threefold.