Antitumor Activity of Symmetrical Selenoesters in Doxorubicin Resistant Breast Cancer.

Background/aim: Previously, selenocompounds (Se-compounds) and in particular selenoesters have shown promising anticancer activities. Since molecular symmetry can enhance the anticancer activity, nine symmetrical selenoesters (Se-esters) have been designed as novel, potentially active anticancer agents against doxorubicin resistant breast cancer cells.

Materials And Methods: To assess the biological effects of the symmetrical Se-esters, the antiproliferative activity was determined on sensitive MCF-7 and doxorubicin resistant KCR breast cancer cell lines.

The Relationship between Antibiotic Susceptibility and pH in the Case of Uropathogenic Bacteria.

Urinary tract infections (UTIs) are common bacterial infections caused mainly by enteric bacteria. Numerous virulence factors assist bacteria in the colonization of the bladder. Bacterial efflux pumps also contribute to bacterial communication and to biofilm formation.

Stable isotope data of daily precipitation during the period of 2013-2017 from K-puszta (regional background monitoring station), Hungary.

Precipitation was collected on daily basis at K-puszta regional background monitoring station located near Kecskemét, in the western part of the Great Hungarian Plain, between 1 April 2013 and 31 December 2017 for stable hydrogen and oxygen analyses. The sample collection period covered 24 hours, from 07:00 to 07:00 h LT (Local Time) the next day. Stable hydrogen and oxygen isotope composition of the daily precipitation samples were measured using a Liquid Water Isotope Analyser (LWIA-24d) manufactured by Los Gatos Research Ltd.