Gene Is Required for Spermatogenesis in the Flatworm .

In a free-living flatworm, , an S-phase kinase-associated protein 1 () homologous gene was identified as enriched in proliferating cells, suggesting that it can function in the regulation of stem cells or germline cells since these are the only two types of proliferating cells in flatworms. is a conserved protein that plays a role in ubiquitination processes as a part of the Skp1-Cullin 1-F-box (SCF) ubiquitin ligase complex. However, the exact role of in was not established.