pH-sensitive CuS@CuS@Au nanoparticles as a drug delivery system for the chemotherapy against colon cancer.

pH-sensitive CuS@CuS@Au nanoparticles (NPs) are successfully prepared by sacrificing template method. The NPs are of hollow structure, which is certified by transmission electron microscopy (TEM). The CuS@CuS@Au NPs can be used as carriers for doxorubicin (DOX).

Gold nanorods contained polyvinyl alcohol/chitosan nanofiber matrix for cell imaging and drug delivery.

Gold nanorods (AuNRs) that contained polyvinyl alcohol/chitosan (PVA/CS) hybrid nanofibers with dual functions are successfully fabricated by a simple electrospinning method. The results of transmission electron microscopy (TEM), X-ray diffraction (XRD) and energy dispersive X-ray (EDX) spectroscopy indicate that AuNRs are indeed encapsulated into the PVA/CS hybrid nanofibers. FTIR spectra results demonstrate that the chemical structures of PVA and CS are not affected when the AuNRs are introduced into the fibers.

Biocompatible core-shell electrospun nanofibers as potential application for chemotherapy against ovary cancer.

Polyvinyl alcohol/chitosan (PVA/CS) core-shell nanofibers are successfully fabricated by a simple coaxial electrospinning method, in which PVA forms the core layer and CS forms the shell layer. With the change of the feed ratio between PVA and CS, the surface morphology and the microstructures of the nanofibers are largely changed. The as-prepared core-shell fibers can be used as a carrier for doxorubicin (DOX) delivery.

Electrospun polyvinyl alcohol/chitosan composite nanofibers involving Au nanoparticles and their in vitro release properties.

Au nanoparticles (Au NPs) containing polyvinyl alcohol (PVA)/chitosan (CS) composite nanofibers were successfully prepared by a simple and effective method called electrospinning. Au NPs were firstly synthesized under a mild condition with CS as the reducing agent and stabilizer, followed by being mixed with PVA solution and then the resulting fibers were fabricated. The research indicated that Au NPs were indeed doped into the as-prepared fibers and the composite fibers well preserved Au NPs' unique optical characteristics.

Polymer/silica hybrid hollow nanospheres with pH-sensitive drug release in physiological and intracellular environments.

Hybrid hollow nanospheres of chitosan-silica templated by chitosan-poly(acrylic acid) nanoparticles are fabricated in a complete aqueous system, which provide a pH-sensitive switch in physiological and sub-cell environments for the release of loaded drug.