Publications by authors named "Erwin Marten Schoof"
Article Synopsis
- Transcription factors PU.1 and CEBPA are crucial for coordinating enhancer activity during the differentiation of granulocytic-monocytic cells into myeloid cells, but their specific roles are not fully understood.
- The study analyzes changes in enhancer dynamics, transcription factor binding, and gene expression in mouse models to reveal how PU.1 and CEBPA regulate these processes differently, with CEBPA showing a pioneering role in enhancer accessibility.
- Findings indicate that CEBPA influences PU.1 levels and is essential for proper differentiation, as its absence leads to an early block in the differentiation process, highlighting their collaborative roles in GM-lineage development.
