Non-iterative model-based inversion for low channel-count optical ultrasound imaginga).

Ultrasound image reconstruction is typically performed using the computationally efficient delay-and-sum algorithm. However, this algorithm is suboptimal for systems of low channel counts, where it causes significant image artefacts. These artefacts can be suppressed through model-based inversion approaches; however, their computational costs typically prohibit real-time implementations.

A fibre-optic ultrasound sensor of simple fabrication.

The small size, high sensitivity, and immunity to electromagnetic interference of fibre-optic ultrasound sensors make them highly attractive for applications in biomedical imaging and metrology. Typically, such sensors rely on optically resonant structures, such as Fabry-Perot cavities, that require elaborate fabrication techniques. Here, an alternative fibre-optic ultrasound sensor is presented that comprises a simple deformable and reflective structure that was deposited using simple dip-coating.

Towards clinical application of freehand optical ultrasound imaging.

Freehand optical ultrasound (OpUS) imaging is an emerging ultrasound imaging paradigm that uses an array of fibre-optic, photoacoustic ultrasound sources and a single fibre-optic ultrasound detector to perform ultrasound imaging without the need for electrical components in the probe head. Previous freehand OpUS devices have demonstrated capability for real-time, video-rate imaging of clinically relevant targets, but have been hampered by poor ultrasound penetration, significant imaging artefacts and low frame rates, and their designs limited their clinical applicability. In this work we present a novel freehand OpUS imaging platform, including a fully mobile and compact acquisition console and an improved probe design.

Low-Field Actuating Magnetic Elastomer Membranes Characterized using Fibre-Optic Interferometry.

Smart robotic devices remotely powered by magnetic field have emerged as versatile tools for wide biomedical applications. Soft magnetic elastomer (ME) composite membranes with high flexibility and responsiveness are frequently incorporated to enable local actuation for wireless sensing or cargo delivery. However, the fabrication of thin ME membranes with good control in geometry and uniformity remains challenging, as well as the optimization of their actuating performances under low fields (milli-Tesla).

Fiber-optic hydrophone for detection of high-intensity ultrasound waves.

Fiber-optic hydrophones (FOHs) are widely used to detect high-intensity focused ultrasound (HIFU) fields. The most common type consists of an uncoated single-mode fiber with a perpendicularly cleaved end face. The main disadvantage of these hydrophones is their low signal-to-noise ratio (SNR).

Enhancement of instrumented ultrasonic tracking images using deep learning.

Purpose: Instrumented ultrasonic tracking provides needle localisation during ultrasound-guided minimally invasive percutaneous procedures. Here, a post-processing framework based on a convolutional neural network (CNN) is proposed to improve the spatial resolution of ultrasonic tracking images.

Methods: The custom ultrasonic tracking system comprised a needle with an integrated fibre-optic ultrasound (US) transmitter and a clinical US probe for receiving those transmissions and for acquiring B-mode US images.

Neural Network Kalman Filtering for 3-D Object Tracking From Linear Array Ultrasound Data.

Many interventional surgical procedures rely on medical imaging to visualize and track instruments. Such imaging methods not only need to be real time capable but also provide accurate and robust positional information. In ultrasound (US) applications, typically, only 2-D data from a linear array are available, and as such, obtaining accurate positional estimation in three dimensions is nontrivial.

Deep Learning for Instrumented Ultrasonic Tracking: From Synthetic Training Data to In Vivo Application.

Instrumented ultrasonic tracking is used to improve needle localization during ultrasound guidance of minimally invasive percutaneous procedures. Here, it is implemented with transmitted ultrasound pulses from a clinical ultrasound imaging probe, which is detected by a fiber-optic hydrophone integrated into a needle. The detected transmissions are then reconstructed to form the tracking image.

Flexible and directional fibre optic ultrasound transmitters using photostable dyes.

All-optical ultrasound transducers are well-suited for use in imaging during minimally invasive surgical procedures. This requires highly miniaturised and flexible devices. Here we present optical ultrasound transmitters for imaging applications based on modified optical fibre distal tips which allow for larger transmitter element sizes, whilst maintaining small diameter proximal optical fibre.

Freehand and video-rate all-optical ultrasound imaging.

All-optical ultrasound (AOUS) imaging, which uses light to both generate and detect ultrasound, is an emerging alternative to conventional electronic ultrasound imaging. To date, AOUS imaging has been performed using paradigms that either resulted in long acquisition times or employed bench-top imaging systems that were impractical for clinical use. In this work, we present a novel AOUS imaging paradigm where scanning optics are used to rapidly synthesise an imaging aperture.

Modelling and measurement of laser-generated focused ultrasound: Can interventional transducers achieve therapeutic effects?

Laser-generated focused ultrasound (LGFU) transducers used for ultrasound therapy commonly have large diameters (6-15 mm), but smaller lateral dimensions (<4 mm) are required for interventional applications. To address the question of whether miniaturized LGFU transducers could generate sufficient pressure at the focus to enable therapeutic effects, a modelling and measurement study is performed. Measurements are carried out for both linear and nonlinear propagation for various illumination schemes and compared with the model.

Source Density Apodization: Image Artifact Suppression Through Source Pitch Nonuniformity.

Conventional ultrasound imaging probes typically comprise finite-sized arrays of periodically spaced transducer elements which, in the case of phased arrays, can result in severe grating and sidelobe artifacts. Whereas side lobes can be effectively suppressed through amplitude apodization ("AmpA"), grating lobes arising from periodicity in transducer placement can only be suppressed by decreasing the element pitch, which is technologically challenging and costly. In this work, we present source density apodization ("SDA") as an alternative apodization scheme, where the spatial source density (and, hence, the element pitch) is varied across the imaging aperture.

All-Optical Rotational Ultrasound Imaging.

Miniaturised high-resolution imaging devices are valuable for guiding minimally invasive procedures such as vascular stent placements. Here, we present all-optical rotational B-mode pulse-echo ultrasound imaging. With this device, ultrasound transmission and reception are performed with light.

Video-rate all-optical ultrasound imaging.

All-optical ultrasound imaging, where ultrasound is generated and detected using light, has recently been demonstrated as a viable modality that is inherently insensitive to electromagnetic interference and exhibits wide bandwidths. High-quality 2D and 3D all-optical ultrasound images of tissues have previously been presented; however, to date, long acquisition times (ranging from minutes to hours) have hindered clinical application. Here, we present the first all-optical ultrasound imaging system capable of video-rate, real-time two-dimensional imaging of biological tissue.

A reconfigurable all-optical ultrasound transducer array for 3D endoscopic imaging.

A miniature all-optical ultrasound imaging system is presented that generates three-dimensional images using a stationary, real acoustic source aperture. Discrete acoustic sources were sequentially addressed by scanning a focussed optical beam across the proximal end of a coherent fibre bundle; high-frequency ultrasound (156% fractional bandwidth centred around 13.5 MHz) was generated photoacoustically in the corresponding regions of an optically absorbing coating deposited at the distal end.

Correlation of Ultrasound Shear Wave Elastography with Pathological Analysis in a Xenografic Tumour Model.

The objective of this study was to evaluate the potential value of ultrasound (US) shear wave elastography (SWE) in assessing the relative change in elastic modulus in colorectal adenocarcinoma xenograft models in vivo and investigate any correlation with histological analysis. We sought to test whether non-invasive evaluation of tissue stiffness is indicative of pathological tumour changes and can be used to monitor therapeutic efficacy. US-SWE was performed in tumour xenografts in 15 NCr nude immunodeficient mice, which were treated with either the cytotoxic drug, Irinotecan, or saline as control.

Pencil beam all-optical ultrasound imaging.

A miniature, directional fibre-optic acoustic source is presented that employs geometrical focussing to generate a nearly-collimated acoustic pencil beam. When paired with a fibre-optic acoustic detector, an all-optical ultrasound probe with an outer diameter of 2.5 mm is obtained that acquires a pulse-echo image line at each probe position without the need for image reconstruction.

Adaptive Light Modulation for Improved Resolution and Efficiency in All-Optical Pulse-Echo Ultrasound.

In biomedical all-optical pulse-echo ultrasound systems, ultrasound is generated with the photoacoustic effect by illuminating an optically absorbing structure with a temporally modulated light source. Nanosecond range laser pulses are typically used, which can yield bandwidths exceeding 100 MHz. However, acoustical attenuation within tissue or nonuniformities in the detector or source power spectra result in energy loss at the affected frequencies and in a reduced overall system efficiency.

Perfectly matched layers for frequency-domain integral equation acoustic scattering problems.

Simulations of acoustic wavefields in inhomogeneous media are always performed on finite numerical domains. If contrasts actually extend over the domain boundaries of the numerical volume, unwanted, non-physical reflections from the boundaries will occur. One technique to suppress these reflections is to attenuate them in a locally reflectionless absorbing boundary layer enclosing the spatial computational domain, a perfectly matched layer (PML).

Source camera identification for heavily JPEG compressed low resolution still images.

In this research, we examined whether fixed pattern noise or more specifically Photo Response Non-Uniformity (PRNU) can be used to identify the source camera of heavily JPEG compressed digital photographs of resolution 640 x 480 pixels. We extracted PRNU patterns from both reference and questioned images using a two-dimensional Gaussian filter and compared these patterns by calculating the correlation coefficient between them. Both the closed and open-set problems were addressed, leading the problems in the closed set to high accuracies for 83% for single images and 100% for around 20 simultaneously identified questioned images.