Composite scaffold of poly(vinyl alcohol) and interfacial polyelectrolyte complexation fibers for controlled biomolecule delivery.

Controlled delivery of hydrophilic proteins is an important therapeutic strategy. However, widely used methods for protein delivery suffer from low incorporation efficiency and loss of bioactivity. The versatile interfacial polyelectrolyte complexation (IPC) fibers have the capacity for precise spatiotemporal release and protection of protein, growth factor, and cell bioactivity.

Evaluation of hemocompatibility and endothelialization of hybrid poly(vinyl alcohol) (PVA)/gelatin polymer films.

Engineered grafts are still needed for small diameter blood vessels reconstruction. Ideal materials would prevent thrombosis and intimal hyperplasia by displaying hemocompatibility and mechanical properties close to those of native vessels. In this study, poly(vinyl alcohol) (PVA)/gelatin blends were investigated as a potential vascular support scaffold.

Customizing the degradation and load-bearing profile of 3D polycaprolactone-tricalcium phosphate scaffolds under enzymatic and hydrolytic conditions.

The degradation of polycaprolactone-20% tricalcium phosphate (PCL-TCP) scaffolds was customized for dentoalveolar augmentation applications, where 5-6 months period is optimal. The scaffolds were treated with either 3M sodium hydroxide (NaOH) or 0.1% lipase solution for a total of 108 h.