Background: Diabetes mellitus (DM) is a chronic metabolic disorder characterized by high blood glucose levels, leading to severe complications over time. Diabetic ketoacidosis (DKA) is a critical acute complication of DM marked by hyperglycemia and acidosis due to ketone body accumulation, often seen in younger patients. The pathophysiology involves insulin deficiency and the effects of counter-regulatory hormones, leading to increased gluconeogenesis and lipolysis.
View Article and Find Full Text PDFAsthma is a chronic airway inflammatory disorder, affecting over 350 million people worldwide, with allergic asthma being the most common form of the disease. Allergic asthma is characterized by a type 2 (T2) inflammatory response triggered by numerous allergens beginning in the airway epithelium, which acts as a physical barrier to allergens as well as other external irritants including infectious agents, and atmospheric pollutants. T2 inflammation is propagated by several key cell types including T helper 2 (Th2) cells, eosinophils, mast cells, and B cells.
View Article and Find Full Text PDFBackground: The present study aimed to comprehensively evaluate the anticancer, anti-inflammatory, and antioxidant properties of Globularia cordifolia L.
Samples: The plant material was collected and extracted using the maceration method. Antioxidant activities were assessed through DPPH (i.
Nanoparticles are attracting attention for their potential therapeutic applications, particularly in cancer therapy, underscoring their importance in medicine. Cadmium sulfide nanoparticles, known for their robust catalytic and optical properties, are classified as chalcogenides and show promise for cancer diagnosis and treatment. Neuroblastoma, a common solid tumor in childhood, poses a significant health threat with different outcomes depending on its biological subtype.
View Article and Find Full Text PDFThe combination of sensing invisible ultraviolet photons and infrared radiation can significantly enhance target recognition by offsetting their own limit in a short sensing range and poor spatial resolution. However, the difference in their wavelength sets unique requirements for sensing materials and devices, which makes it hard to establish their implementation in a single detector. In this work, we present the design of a single detector with CHNHPbCl (MAPbCl) for distinguishing ultraviolet and IR signals by switching its operating mode in the photo-/thermo-electric effect.
View Article and Find Full Text PDFParkinson's disease (PD) is a chronic neurodegenerative case. As the disease progresses, the response time to doses of levodopa (L-Dopa) becomes shorter and the effects of the drug are severely limited by some undesirable side effects such as the 'on-off' phenomenon. In several diseases, including Parkinson's, nanoparticles can deliver antioxidant compounds that reduce oxidative stress.
View Article and Find Full Text PDFBackground: Doxorubicin is an effective antineoplastic agent but has limited clinical application because of its cumulative toxicities, including cardiotoxicity. Cardiotoxicity causes lipid peroxidation, genetic impairment, oxidative stress, inhibition of autophagy, and disruption of calcium homeostasis. Doxorubicin-induced cardiotoxicity is frequently tried to be mitigated by phytochemicals, which are derived from plants and possess antioxidant, anti-inflammatory, and anti-apoptotic properties.
View Article and Find Full Text PDFBackground: A promising recent strategy for haploidentical transplantation is the depletion of T lymphocytes based on the selective elimination of T cells by manipulation, which enables a very low incidence of nonrelapse mortality and graft-vs-host disease. It is more expensive than conventional unmanipulated methods and requires dedicated transplant centers and sufficient stem cell processing facilities. This retrospective study aimed to evaluate the relapse, survival, and clinical data of the patients and to analyze the outcomes of the technique.
View Article and Find Full Text PDFObjectives: Bee venom is used for medicinal purposes, including the treatment of neurological and liver diseases, but its use as a primary health care approach for preventive purposes requires further exploration. The aim of this study was to provide the first investigation into the possible protective effects of bee venom against hepatic encephalopathy, a serious neurodegenerative disease.
Materials And Methods: An experimental animal study was conducted in which healthy albino Sprague-Dawley rats were randomized into three groups: healthy, control and bee venom groups.
Objectives: The artificial intelligence competition in healthcare at TEKNOFEST-2022 provided a platform to address the complex multi-class classification challenge of abdominal emergencies using computer vision techniques. This manuscript aimed to comprehensively present the methodologies for data preparation, annotation procedures, and rigorous evaluation metrics. Moreover, it was conducted to introduce a meticulously curated abdominal emergencies data set to the researchers.
View Article and Find Full Text PDFAgents that will accelerate wound healing maintain their clinical importance in all aspects. The aim of this study is to determine the antimicrobial activity of zinc oxide nanoparticles (ZnO NPs) ZnO nanoparticles obtained by green synthesis from Capparis spinosa L. extract and their effect on in vitro wound healing.
View Article and Find Full Text PDFDecellularization is a process by which cells are removed from tissues or organs, leaving behind the extracellular matrix (ECM) structure. This process has gained interest in the fields of tissue engineering and regenerative medicine as a way to prepare suitable scaffolds for tissue reconstruction. Although the initial efforts come with the animal tissues, this technique can also be applied to various plant tissues with simple modifications, as plant-derived biomaterials have the benefit of being biocompatible and serving as a safe, all-natural substitute for synthetic or animal originated materials.
View Article and Find Full Text PDFDecellularization is one of a promising technique in the field of biomaterials based on the idea of using an acellular construct, here the organ / tissue itself, as a biocompatible and biological construct. In the decellularization process, the main objective is to preserve the structural and functional properties while removing living cells. In the current paper, we describe an electrochemical method for soft tissue decellularization at a specific voltages and time intervals, as well as further DNA, GAG, protein determinations, and histological examinations for the determination of decellularization efficacy.
View Article and Find Full Text PDFColloidal quantum dots (QDs) are promising luminescent materials for display and lighting, but their stability has long been an issue. Here, we designed a passivation strategy of doping Ti ions into the shell of alloyed CdZnSeS@ZnS QDs. The results showed that Ti ions were successfully doped into the ZnS shell and the stability of QDs was improved.
View Article and Find Full Text PDFNanotechnology
August 2022
Taking into account the novel layered structure and unusual electronic properties of MoSand WSon the side the lack of dangling bonds between these two components and donor-acceptor linkage effects, growth of the MoS/WSvertical heterojunction film on the amorphous SiO/Si substrate have created high demand. In this study, we reported the continuous, scalable, and vertical MoS/WSheterostructure film by using a sputtering without a transfer step. The WSfilm was continuously grown on MoSand eventually led to the formation of the MoS/WSvertical heterojunction film.
View Article and Find Full Text PDFACS Appl Mater Interfaces
July 2022
Quantum dots (QDs) have attracted much attention as one of the most promising candidates for next-generation display materials. However, stability is still a big challenge for QDs. Herein, we encapsulated QDs in a thermoplastic polypropylene (PP) matrix by thermal processing technology to prepare a stabler color conversion film for the first time.
View Article and Find Full Text PDFTurk J Phys Med Rehabil
December 2021
Diabetes is one of the most common health problems worldwide. Diabetic foot wounds (DFWs) are hazardous complications of the disease. Patients are often referred to rehabilitation facilities at later stages of the diabetic complications, particularly after amputation surgery.
View Article and Find Full Text PDFObjective: The cytokine storm presented in the hyperimmune response is related to poor prognosis in people with COVID-19. Interleukin-6 (IL-6) is one of the most prominent cytokines, especially on mucosal surfaces during infection, causing the cytokine storm. Polyunsaturated fatty acids (PUFAs) are the precursors of eicosanoids, which play critical roles in immune regulation and inflammation.
View Article and Find Full Text PDFBackground: Myiasis is a parasitic infestation of tissues or body cavities of mammals with dipterous larvae. The patients with diabetic foot ulcers are more vulnerable to acquiring infestation; however, the infestation may be neglected and mistreated in some cases.
Methods: Data were collected of twelve myiasis cases with diabetic foot ulcers in Nazli-Selim Eren Chronic Wound and Infections Care Unit, Aydin, Turkey between 2017 and 2019.
This study was designed to investigate the protective effects of Centella asiatica (CA) on cisplatin-induced hepatotoxicity and to clarify the underlying mechanism by biochemical, molecular, immunohistochemical, and histopathological analyses. Rats were pre-treated with two doses of CA (100 and 200 mg/kg, p.o.
View Article and Find Full Text PDFThe objective of this study was to elucidate the effects of syringic acid on thioacetamide-induced hepatic encephalopathy which is a complex serious syndrome with neuropsychiatric abnormalities related to acute liver dysfunctions like cirrhosis. Rats were treated with syringic acid (50 and 100 mg/kg, p.o.
View Article and Find Full Text PDFObjective: To determine the factors affecting the quality of life of patients with chronic wounds.
Methods: This descriptive cross-sectional study was conducted in a university hospital wound care unit in western Turkey with 134 patients. The data were collected via personal information form, Barthel Index for activities of daily living, visual analog scale, and Short Form-12 questionnaire.
The soil-bearing capacity is one of the important criteria in dimensioning the superstructure. In Turkey, predictability of California Bearing Ratio values, which may be used in the planning and dimensioning of forest roads, of which about 26% lacks the superstructure, by using soil mechanical properties (cost and time efficient parameters that are easier to determine) is investigated. Simple linear regression, multiple linear regression, artificial neural networks and adaptive network-based fuzzy inference system methods were utilized.
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