Atypical glandular cells (AGC): ThinPrep Imaging System (TIS), manual screening (MS), and correlation with Hybrid Capture 2 (HC2) HPV DNA testing.

Objective: The aim of the study was to determine if the ThinPrep Imaging System (T1S) improves the positive predictive value (PPV) of atypical glandular cell (AGC) diagnosis for identifying HPV-related squamous and/or glandular lesions over manual screening (MS), and if human papilloma virus (HPV)-DNA testing improves the diagnostic yield.

Materials And Methods: 85 ThinPrep cervical cytology specimens with a diagnosis of AGC by TIS (n = 51) and MS (n = 34) were retrieved. The diagnoses were correlated with corresponding histologic follow-up and high risk (HR)-HPV testing results.

The Bethesda System 2001 recommendation for reporting of benign appearing endometrial cells in Pap tests of women age 40 years and older leads to unwarranted surveillance when followed without clinical qualifiers.

Objectives: The purpose of this study is to determine the impact of the Bethesda System 2001 recommendation of reporting cytologically benign appearing endometrial cells (BEC) seen in Papanicolaou (Pap) tests of all women age 40 years and older, and to determine the significance of such finding.

Methods: Pap tests of women age 40 years and older containing BEC outside of the first half of menstrual cycle reported before and after the Bethesda System 2001 implementation were included. 300 postmenopausal women without BEC were included as control group.

High-risk human papillomavirus DNA testing: a marker for atypical glandular cells.

Cervical/endocervical cytology screening has decreased morbidity and mortality, and implementing adjunctive human papilloma virus (HPV) DNA testing for atypical squamous cells of undetermined significance has improved the specificity for detecting premalignant squamous lesions. Currently, there are no guidelines to perform HPV DNA testing on cervical/endocervical ThinPreps with atypical glandular cells (AGC). To assess the potential role of HPV DNA testing on AGC cases, Hybrid Capture 2 (Digene Corp.

Comparison of human papillomavirus DNA prevalence in atypical squamous cells of undetermined significance subcategories as defined by the original Bethesda 1991 and the new Bethesda 2001 Systems.

Context: The new Bethesda System 2001 (TBS 2001) minimized the subclassification of atypical squamous cells of undetermined significance (ASCUS).

Objective: The primary goal of this study was to determine the impact of the new subclassification on the accuracy of Papanicolaou (Pap) test diagnosis by examining the prevalence of human papillomavirus (HPV) DNA in different ASCUS subcategories, as defined by the new TBS 2001 versus the original TBS 1991. The second goal was to identify specific morphologic features of atypical squamous cells that are more frequently associated with HPV detection.

Utility of the cervical cytologic smear in assessing endocervical involvement by endometrial carcinoma.

Objective: To evaluate the possible contribution of cervical cytology in the identification of high-risk endometrial cancer patients.

Study Design: A retrospective study of 61 patients who had a preoperative cervical cytologic smear and hysterectomy at our institution for endometrial carcinoma. The smear and endocervical curetting (ECC) results were compared with the status of the endocervix in the hysterectomy specimens.

Cytologic characteristics of tubulolobular carcinoma of the breast.

Objective: To determine the cytologic characteristics of tubulolobular carcinoma, a rare tumor of the breast in which the histologic features of both tubular and lobular carcinoma are combined.

Study Design: Review of fine needle aspirates and corresponding intraoperatively prepared touch imprints of eight cases of tubulolobular carcinoma.

Results: Low nuclear grade of tumor cells, low mitotic activity, intracytoplasmic vacuoles, single filing of cells and presence of tubular structures were observed in both preparations in most cases.