Publications by authors named "Erpelding M"
Objectives: The recent Flare-OA questionnaire measuring flare in knee and hip osteoarthritis (OA) (19 items in 5 domains, numerical rating scale) showed good psychometric properties along with classical test theory. This study aimed to determine its scaling properties by Rasch analysis and to present evidence for a refined scalable version.
Study Design And Setting: The participants were 398 subjects (mean age 64 years [standard deviation = 8.
Objectives: This study aims to compare methods of constructing a composite score for the Flare-OA-16 self-reported questionnaire.
Methods: Participants with knee and hip osteoarthritis (OA) completed a validated 16-item questionnaire assessing five domains of flare. Three estimation methods were compared: (i) second-order confirmatory factor analysis (CFA); (ii) logistic regression, according to the participant's self-report of flare (yes/no); and (iii) Rasch method, with weighted scores in each dimension.
Introduction: Anal carcinoma is a relatively uncommon tumor that accounts for less than 2% of large bowel malignancies and approximately 1-6% of anorectal tumors. Most anal cancers originate in the mucosa between the anorectal junction and the anal verge. Risk factors for anal carcinoma include human papillomavirus (HPV), immunosuppression, older age, female gender, and smoking.
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- The study aimed to assess how well the AEPEI surgical score predicts outcomes in patients undergoing surgery for infective endocarditis (IE), compared to other risk scores like EuroSCORE and De Feo.
- It enrolled patients from two hospitals in France over various years, excluding those with IE from certain procedures, and evaluated the scores using different statistical methods.
- Results showed that the AEPEI score had superior predictive performance and calibration for in-hospital mortality, indicating it may be a valuable tool for clinicians managing IE surgery.
Introduction: F-FDG-PET/CT is recommended to improve the diagnosis of prosthetic valve infective endocarditis (PVIE) and is a major criterion in the ESC-2015 classification. However, there is little evidence for its usefulness in the follow-up of medically treated PVIE patients.
Methods: A monocentric retrospective analysis of patients hospitalized for PVIE between January 2013 and December 2019 who were not treated with surgery and who had at least two F-FDG-PET/CT examinations during their medical management.
Article Synopsis
- The study investigated the use of transoesophageal echocardiography (TEE) in elderly patients (≥75 years) with infective endocarditis (IE) and its effects on their treatment and mortality rates.
- It found that older patients who did not undergo TEE had worse overall health, fewer surgeries indicated, and higher mortality rates, despite having similar IE characteristics compared to those who had TEE.
- The research highlights the importance of TEE in accurately diagnosing cardiac lesions and improving management, suggesting that underdiagnosis in older patients could lead to poorer outcomes.
Article Synopsis
- The study aimed to analyze patients with both infective endocarditis (IE) and bacterial meningitis (BM), merging data from two large cohorts to explore their characteristics.
- Out of 1030 patients, 42 had both conditions, with meningitis being the primary admission presentation and the most common pathogens identified as Streptococcus pneumoniae and Staphylococcus aureus.
- The findings indicate that patients with this dual infection have a higher mortality rate compared to those with only IE or BM, highlighting the need for early diagnosis and treatment.
Article Synopsis
- A study on infective endocarditis (IE) highlighted significant differences between patients with and without underlying cardiac conditions (UCC), finding that those without UCC were generally younger and had distinct comorbidities like malignancy and immune deficiency.
- Patients without UCC experienced more severe complications, such as larger vegetations, higher rates of valve issues, and a greater likelihood of requiring valve surgery.
- Despite the increased severity of their condition, in-hospital mortality rates were similar between both groups, suggesting that age and specific health conditions influenced the disease course rather than mortality outcomes.
Background: Despite guidelines describing the optimal diagnostic and therapeutic procedures for patients with suspected cardiac implantable electronic device (CIED) infections, their management is often challenging.
Aims: To describe our diagnostic and therapeutic practices for suspected CIED infection, and to compare them with European Heart Rhythm Association (EHRA) guidelines.
Methods: Patients hospitalized in the tertiary care Nancy University Hospital for suspected CIED infection from 2014 to 2019 were included retrospectively.
Article Synopsis
- The article discusses supplementary tables and figures related to a research paper that analyzes referral bias in patients with infective endocarditis, using data from a population-based cohort study.
- It includes 497 patients diagnosed in 2008, categorized into three groups based on their hospital admissions, to examine the effects of referral bias on patient outcomes.
- The findings suggest that referral bias—favoring patients from tertiary hospitals—can significantly alter survival estimates and the identification of prognostic factors, as depicted in the six tables that compare selection impacts.
Article Synopsis
- This study examines referral bias in prognostic research for infective endocarditis by comparing characteristics and outcomes of patients from different hospital admission types.
- It analyzed data from 497 patients, categorizing them into three groups based on how they were admitted to hospitals: directly to a tertiary hospital, referred from a non-tertiary hospital, or admitted to a non-tertiary hospital.
- The findings revealed significant differences in patient demographics, surgical needs, and survival rates among the groups, indicating that referral bias can impact the accuracy of clinical characteristics and prognostic estimates.
Background: Increased access to heart valves through early surgery and progress in molecular microbiology have reduced the proportion of infective endocarditis (IE) with no microbiological documentation and increased the proportion of IE associated with unusual microorganisms.
Methods: We performed an ancillary study of a large prospective population-based survey on IE. Unusual-microorganism IE was defined as definite IE (Duke-Li criteria) due to microorganisms other than streptococci, staphylococci, or enterococci.
Objective: The Flare Assessment in Rheumatoid Arthritis (FLARE-RA) questionnaire was devised for the detection of flares in patients with RA. We aimed to define construct validity and cut-off(s) for the FLARE-RA questionnaire.
Methods: This cross-sectional study included adult patients with prevalent RA (2010 ACR/EULAR criteria) attending outpatient rheumatology clinics in France (n = 138), Denmark (n = 253), USA (n = 75), and Argentina (n = 105).
Background: The Global Physical Activity Questionnaire (GPAQ) has been used to measure physical activity (PA) and sedentary time in France, but no study has assessed its psychometric properties. This study aimed to compare the reliability as well as criterion and concurrent validity of the French version of the GPAQ with the French International Physical Activity Questionnaire long form (IPAQ-LF) and use of an accelerometer in a general adult population.
Methods: We included 92 participants (students or staff) from the Medicine Campus at the University of Lorraine, Nancy (north-eastern France).
Objectives: Time to blood culture positivity (TTP), a routinely available parameter in automated blood culture systems, may be a proxy for infectious burden in patients with bloodstream infections. We aimed to study the association between TTP and infective endocarditis (IE), or death, in patients with Staphylococcus aureus bacteraemia.
Methods: VIRSTA is a multicentre prospective cohort study that included all adult patients with S.
infective endocarditis (SaIE) is a severe complication of bacteremia (SAB) occurring in up to 22% of patients. Bacterial genetic factors and host conditions for SaIE have been intensely studied before; however, to date no study has focused on predisposing host genetic factors to SaIE. The present study aimed to identify genetic polymorphisms associated with SaIE by a Genome-Wide Association Study (GWAS) of 67 patients with definite native valve SaIE (cases) and 72 matched native valve patients with SAB but without IE (controls).
View Article and Find Full Text PDFWe aimed to identify trajectories of nutrition, cognitive function, and autonomy over time among very old adults and to assess their impact on mortality. A cohort of subjects aged ≥80 years (in 2007-2008) who were followed for 5 years in 72 Italian and French nursing homes was used for post hoc analyses. Body mass index (BMI; weight (kg)/height (m)2), Mini-Mental State Examination (MMSE) score, and Katz Index of Independence in Activities of Daily Living (ADL) score were assessed at 4 time points.
View Article and Find Full Text PDFObjective: Antiphospholipid (aPL) antibodies may activate platelets and contribute to vegetation growth and embolisation in infective endocarditis (IE). We aimed to determine the value of aPL as predictors of embolic events (EE) in IE.
Methods: We studied 186 patients with definite IE (Duke-Li criteria, all types of IE) from the Nanc-IE prospective registry (2007-2012) who all had a frozen blood sample and at least one imaging procedure to detect asymptomatic or confirm symptomatic EE.
Article Synopsis
- The study aimed to assess how the timing of diagnosis impacts the characteristics and outcomes of infective endocarditis (IE), comparing cases diagnosed within one month of first symptoms to those diagnosed later.
- Of the 486 IE cases analyzed, 25% were diagnosed late; early diagnosis was linked to female patients, prosthetic valves, and specific pathogens like staphylococci.
- The findings indicated that while in-hospital mortality was higher in early-diagnosed cases, late diagnosis allowed for more valve surgeries and better overall prognosis.
Objective: To validate the measurement properties and the detection performance of the FLARE-RA questionnaire in a longitudinal prospective study.
Methods: To validate the FLARE-RA self-administered questionnaire, we conducted a prospective trial in rheumatoid arthritis (RA) patients to document: 1) content and construct validity by factor analysis, convergent validity by Pearson's correlation with routine assessment of patient index data (Routine Assessment of Patient Index Data 3 [RAPID-3] questionnaire), RA Impact of Disease (RAID) score, Disease Activity Score in 28 joints (DAS28), and Health Assessment Questionnaire (HAQ), 2) reliability (intraclass correlation coefficient [ICC] and Bland-Altman plot), and 3) feasibility of use. Patients were examined and questionnaires were collected at baseline and 3 months, and every week in between for RAPID-3.
Objectives: To develop and validate a prediction score, to quantify, within 48 h of Staphylococcus aureus bacteremia (SAB) diagnosis, the risk of IE, and therefore determine priority for urgent echocardiography.
Methods: Consecutive adult patients with SAB in 8 French university hospitals between 2009 and 2011 were prospectively enrolled and followed-up 3 months. A predictive model was developed and internally validated using bootstrap procedures.
Background: Right ventricular (RV) dysfunction is an important predictor of impaired prognosis in idiopathic dilated cardiomyopathy.
Aims: To determine the prognostic role of RV dysfunction, independent of left ventricular (LV) dysfunction.
Methods: A total of 136 consecutive patients (73% men; mean age 59.
Objectives: To update the epidemiology of S. aureus bloodstream infection (SAB) in a high-income country and its link with infective endocarditis (IE).
Methods: All consecutive adult patients with incident SAB (n = 2008) were prospectively enrolled between 2009 and 2011 in 8 university hospitals in France.
Background: The impact of early valve surgery (EVS) on the outcome of Staphylococcus aureus (SA) prosthetic valve infective endocarditis (PVIE) is unresolved. The objective of this study was to evaluate the association between EVS, performed within the first 60 days of hospitalization, and outcome of SA PVIE within the International Collaboration on Endocarditis-Prospective Cohort Study.
Methods: Participants were enrolled between June 2000 and December 2006.