Microstructure evolution and mechanical behavior of foamed cement-based tail backfills under varying fiber types and concentrations.

Industrial solid waste (mine tailings) management has emerged as the key universal ecological challenge as a result of the unceasing creation of rising waste by-products. Employing tailings makes mine fill production economical and assists resolve disposal problems. Foamed cement-based tailings backfill (FCTB) is a mine fill consisting of tailing, cement, water, and foaming agents.

Microstructure and mechanical behavior of cemented gold/tungsten mine tailings-crushed rock backfill: Effects of rock gradation and content.

Without appropriate and responsible waste management in place, the cursory storage of tailings and waste rocks on the surface can cause devastating damage to the planet's ecosystems. To proactively manage or abolish the damage, some techniques such as mine backfill have been already used repeatedly in mines. Microstructure and strength behavior of cementitious tailings-crushed rock backfill (CTCRB) with gold/tungsten tailings and rock contents (e.

Physico-chemical and micro-structural behavior of cemented mine backfill: Effect of pH in dam tailings.

The tailings created during ore processing have been a serious problem for mining companies and environment since it is a challenging task to effectively manage these highly voluminous/dangerous tailings. Therefore, several tailings disposal methods like tailings dams are needed for sustainable mining operations. The tailings accumulated in the dams reflect a critical raw material source since they might contain key base/precious metals, such as Au, Ag, Co, Ni, Cu and Zn.

Impact of sex-specific target dose in chronic heart failure patients with reduced ejection fraction.

Aims: A recent study suggested that women with heart failure and heart failure reduced ejection fraction might hypothetically need lower doses of angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers ( = renin-angiotensin-system inhibitors) and β-blockers than men to achieve the best outcome. We assessed the current medical treatment of heart failure reduced ejection fraction in men and women in a large contemporary cohort and address the hypothetical impact of changing treatment levels in women.

Methods: This analysis is part of a large contemporary quality of heart failure care project which includes 5320 (64%) men and 3003 (36%) women with heart failure reduced ejection fraction.

Contemporary use of devices in chronic heart failure in the Netherlands.

Aims: Despite previous surveys regarding device implantation rates in heart failure (HF), insight into the real-world management with devices is scarce. Therefore, we investigated device implantation rates in HF with reduced left ventricular ejection fraction (LVEF) in 34 Dutch centres.

Methods And Results: A cross-sectional outpatient registry was conducted in 6666 patients with LVEF < 50% and with information about device implantation available [74 (66-81) years of age; 64% male].

Ultrasonic evaluation of strength properties of cemented paste backfill: Effects of mineral admixture and curing temperature.

This paper presents the findings of a research study designed and conducted to investigate the effects of mineral admixture and curing temperature on uniaxial compressive strength (UCS) and ultrasonic pulse velocity (UPV) behavior of laboratory-prepared cemented paste backfill (CPB) samples. A total of 290 CPB samples were prepared at different replacement rates (10-80%), cured at various temperatures (10-50 °C), and respectively subjected to both UPV and UCS testing after curing times of 3, 7, 14, 28, 56 and 90 days. The obtained experimental results show that the addition of fly ash (FA) can lead to an increase or decrease trend in UCS and UPV behavior of CPB samples, depending on the replacement level of admixtures.

In vitro and in vivo drug release from a novel in situ forming drug delivery system.

Purpose: The objective of this work was to investigate the influence of various preparation and formulation parameters on the in vitro and in vivo release of bupivacaine hydrochloride from an injectable in situ forming microparticle system (ISM).

Methods: The in vitro drug release of ISM was investigated as a function of various formulation and process parameters and was compared to the drug release from in situ forming implants and conventional microparticles. In vivo studies were carried out in male Sprague-Dawley rats.

Cardiac resynchronization improves microcirculation.

Background: Although it is known that cardiac resynchronization therapy (CRT) in heart failure (HF) patients improves systemic circulation, its acute effects on microcirculation are as yet unknown. Therefore we investigated the sublingual microcirculatory changes in HF patients from CRT and right ventricular (RV) pacing by use of orthogonal polarization spectral (OPS) imaging.

Methods And Results: Twelve consecutive HF patients with a CRT device and 20 healthy individuals (HI) were included.

Effect of lipid-containing, positively charged nanoemulsions on skin hydration, elasticity and erythema--an in vivo study.

Dry skin and other skin disorders such as atopic dermatitis are characterized by impaired stratum corneum (SC) barrier function and by an increase in transepidermal water loss (TEWL) leading to a decrease in skin hydration. The possibility that dermatological and cosmetic products containing SC lipids could play a part in the restoration of disturbed skin barrier function is of great interest in the field of dermatology and cosmetics. The aim of the present study was to evaluate the effect of positively charged oil/water nanoemulsions (PN) containing ceramide 3B and naturally found SC lipids (PNSC) such as ceramide 3, cholesterol, and palmitic acid on skin hydration, elasticity, and erythema.

Varying the heart rate response to dynamic exercise in pacemaker-dependent subjects: effects on cardiac output and cerebral blood velocity.

Cerebral blood flow increases upon the transition from rest to moderate exercise, but becomes affected when the ability to raise CO (cardiac output) is limited. HR (heart rate) is considered to contribute significantly to the increase in CO in the early stages of dynamic exercise. The aim of the present study was to test whether manipulation of the HR response in patients dependent on permanent rate-responsive ventricular pacing contributes to the increase in CO, MCA V(mean) [mean MCA (middle cerebral artery) velocity] and work capacity during exercise.

Design of a phytosphingosine-containing, positively-charged nanoemulsion as a colloidal carrier system for dermal application of ceramides.

Positively charged oil/water (o/w) nanoemulsions (PN) are effective vehicles to change the permeability of the skin. This study focused on the preparation and characterisation of phytosphingosine (PS) containing PN (PPN) which serve as colloidal carriers for the dermal application of ceramide IIIB (CIIIB) and the stratum corneum (SC) lipids (PPNSC) such as ceramide III (CIII), cholesterol, and palmitic acid. The investigations were conducted using appropriate emulsification and homogenisation processing conditions to optimise PPNSC with regard to droplet size, physical stability, and solubility of PS, CIII and CIIIB.

Cardiac resynchronization induces favorable neurohumoral changes.

Aim: The aim of this article is to examine whether cardiac resynchronization therapy (CRT) induces improvements in the neurohumoral system.

Methods And Results: Thirteen patients with HF (left ventricular (LV) ejection fraction <35%) were included. Before and after 6 months of CRT, myocardial (123)I-metaiodobenzylguanidine ((123)I-MIBG) uptake indices, used as an index of neural norepinephrine reuptake and retention, and brain natriuretic peptide (BNP) levels, used as an index of LV end-diastolic pressure, NYHA classification and echocardiographic indices were assessed.

Individual optimization of pacing sensors improves exercise capacity without influencing quality of life.

Introduction: Programmable pacemaker sensor features are frequently used in default setting. Limited data are available about the effect of sensor optimization on exercise capacity and quality of life (QOL). Influence of individual optimization of sensors on QOL and exercise tolerance was investigated in a randomized, single blind study in patients with VVIR, DDDR, or AAIR pacemakers.

Direct comparison of a contractility and activity pacemaker sensor during treadmill exercise testing.

There are limited data about the chronotropic capacity of the peak endocardial acceleration (PEA) sensor. This study directly compared the chronotropic function from the PEA and the activity (ACT) sensor. The study included 18 patients (age 73 +/- 7 years) with > or = 75% pacemaker-driven heart rate (HR) and a PEA sensor and 11 healthy controls (age 67 +/- 7 years) underwent a chronotropic assessment exercise protocol (CAEP) exercise test with the pacemaker patients in VVIR mode after programming the sensors in the default setting with adjustment of the upper sensor rate as an age related maximum value (220-age).

Reversed remodelling of dilated left sided cardiomyopathy after upgrading from VVIR to VVIR biventricular pacing.

Aims: To show reversed remodelling of the left ventricle and left atrium after upgrading to biventricular pacing in a patient with worsening heart failure due to VVIR pacing. To review the literature concerning reversed remodelling after upgrading to biventricular pacing.

Methods And Results: In a 61-year-old man, with cardiomyopathy and worsening heart failure and mitral insufficiency following conventional pacing after His-bundle ablation, upgrading to biventricular pacing showed left sided reversed remodelling of the heart with decrease in mitral regurgitation in 6 months.