Regime switching in coupled nonlinear systems: Sources, prediction, and control-Minireview and perspective on the Focus Issue.

Regime switching, the process where complex systems undergo transitions between qualitatively different dynamical states due to changes in their conditions, is a widespread phenomenon, from climate and ocean circulation, to ecosystems, power grids, and the brain. Capturing the mechanisms that give rise to isolated or sequential switching dynamics, as well as developing generic and robust methods for forecasting, detecting, and controlling them is essential for maintaining optimal performance and preventing dysfunctions or even collapses in complex systems. This Focus Issue provides new insights into regime switching, covering the recent advances in theoretical analysis harnessing the reduction approaches, as well as data-driven detection methods and non-feedback control strategies.

The Statistics of -Statistics.

Almost two decades ago, Ernesto P. Borges and Bruce M. Boghosian embarked on the intricate task of composing a manuscript to honor the profound contributions of Constantino Tsallis to the realm of statistical physics, coupled with a concise exploration of -Statistics.

Fully automated sequential immunofluorescence (seqIF) for hyperplex spatial proteomics.

Tissues are complex environments where different cell types are in constant interaction with each other and with non-cellular components. Preserving the spatial context during proteomics analyses of tissue samples has become an important objective for different applications, one of the most important being the investigation of the tumor microenvironment. Here, we describe a multiplexed protein biomarker detection method on the COMET instrument, coined sequential ImmunoFluorescence (seqIF).

Reconstructing Network Dynamics of Coupled Discrete Chaotic Units from Data.

Reconstructing network dynamics from data is crucial for predicting the changes in the dynamics of complex systems such as neuron networks; however, previous research has shown that the reconstruction is possible under strong constraints such as the need for lengthy data or small system size. Here, we present a recovery scheme blending theoretical model reduction and sparse recovery to identify the governing equations and the interactions of weakly coupled chaotic maps on complex networks, easing unrealistic constraints for real-world applications. Learning dynamics and connectivity lead to detecting critical transitions for parameter changes.

Causes of severe infections in patients with systemic sclerosis and associated factors.

Background: Systemic sclerosis (SSc) is a chronic systemic disease characterized by vascular damage, autoimmunity, and fibrosis in the skin and internal organs. In this study, we tried to determine the causes of severe infection in patients with SSc and to reveal the factors associated with severe infection.

Methods: We retrospectively examined 214 SSc patients between January 2010 and August 2020.

Efficacy of nasal stimulants on interpersonal communication - a narrative review.

The aim of this paper is to review the use of nasal stimulants in interpersonal communication. The literature survey was performed from PubMed, ProQuest Central database of Anadolu University, and Google Scholar. Throughout history, various materials have been used as nasal stimulants to communicate and socialize intensively.

Emergent hypernetworks in weakly coupled oscillators.

Networks of weakly coupled oscillators had a profound impact on our understanding of complex systems. Studies on model reconstruction from data have shown prevalent contributions from hypernetworks with triplet and higher interactions among oscillators, in spite that such models were originally defined as oscillator networks with pairwise interactions. Here, we show that hypernetworks can spontaneously emerge even in the presence of pairwise albeit nonlinear coupling given certain triplet frequency resonance conditions.

Network structural origin of instabilities in large complex systems.

A central issue in the study of large complex network systems, such as power grids, financial networks, and ecological systems, is to understand their response to dynamical perturbations. Recent studies recognize that many real networks show nonnormality and that nonnormality can give rise to reactivity-the capacity of a linearly stable system to amplify its response to perturbations, oftentimes exciting nonlinear instabilities. Here, we identify network structural properties underlying the pervasiveness of nonnormality and reactivity in real directed networks, which we establish using the most extensive dataset of such networks studied in this context to date.

Sampling rate-corrected analysis of irregularly sampled time series.

The analysis of irregularly sampled time series remains a challenging task requiring methods that account for continuous and abrupt changes of sampling resolution without introducing additional biases. The edit distance is an effective metric to quantitatively compare time series segments of unequal length by computing the cost of transforming one segment into the other. We show that transformation costs generally exhibit a nontrivial relationship with local sampling rate.

Publisher's Note: Entropy of weighted recurrence plots [Phys. Rev. E 90, 042919 (2014)].

This corrects the article DOI: 10.1103/PhysRevE.90.

Interstitial Lung Disease in Systemic Sclerosis: A Single-center Retrospective Analysis.

Background: Systemic sclerosis (SSc) is a systemic autoimmune disease characterized by microangiopathy, inflammation, fibrosis. Interstitial lung disease (ILD) is common among SSc patients.

Objective: This study aims to define the clinical, laboratory, and serologic characteristics of SSc patients with ILD and to present the frequency of chest computed tomography features.

Serum Calprotectin is Indicating Clinical and Ultrasonographic Disease Activity in Rheumatoid Arthritis, even with Normal C-Reactive Protein Levels.

Objective: Calprotectin is an inflammatory biomarker which assesses disease activity in rheumatoid arthritis (RA). The objective of this study was to test whether serum calprotectin is associated with clinical and ultrasonographic disease activity in patients with RA, and to analyse its predicting value for disease activity evaluation despite normal C-Reactive protein (CRP) levels.

Methods: We included 80 patients with RA and 30 healthy subjects.

High mobility group box-1 levels may be associated with disease activity of Behcet's disease.

Background: High mobility group box- 1 (HMGB- 1) is a nuclear protein acting as a proinflammatory molecule. The serum HMGB- 1 levels were found elevated in chronic inflammatory diseases. In this cross-sectional study, serum HMGB- 1 levels in Behcet's disease (BD) patients and healthy controls (HC) were studied.

Patient characteristics in Behçet's Syndrome and their associations with major organ involvement: a single-centre experience of 2118 cases.

: To evaluate the demographic and clinical characteristics of patients with Behçet's syndrome (BS), and to define their associations with the presence of major organ involvement (MOI).: Medical records of 2118 patients (964 males, 1154 females) were analysed retrospectively. MOI was defined as the presence of at least one of vascular, eye, nervous, or gastrointestinal system involvement.

Clinical characteristics of pulmonary artery involvement in patients with Behçet's syndrome: single-centre experience of 61 patients.

Objective: To report the clinical characteristics of pulmonary artery involvement (PAI) in patients with Behçet's syndrome (BS) and to define the predictors of relapses.

Methods: We performed retrospective analysis of BS patients with PAI who fulfilled international study group criteria. Among 460 patients with vascular Behçet's syndrome (VBS), 66 were diagnosed with PAI.

The relationship between serum bicarbonate, pH level and sleep quality in haemodialysis patients: A cross-sectional study from Turkey.

Objective: To investigate the relationship of blood pH and bicarbonate levels with sleep disorders in patients with end-stage renal disease.

Methods: The cross-sectional study was conducted at Kocaeli Derince Health Practice and Research Center, Kocaeli, Turkey, in July 2015, and comprised stable haemodialysis patients aged over 18 years who had undergone at least 3 months of treatment. The Pittsburgh sleep quality index was used to assess sleep quality, and the Epworth sleepiness scale was used to assess sleepiness.

Determination of the microbial flora in traditional İzmir Tulum cheeses by Denaturing Gradient Gel Electrophoresis.

In this study, it was aimed to determine microbial flora members in three traditional Tulum cheeses (C1, C2 and C3) produced in different villages and settlement areas in İzmir, Turkey. For this purpose, culture depended and 16S rRNA based culture independent methods were used. According to the results of culture depended method, spp.

In Vitro Detection System to Evaluate the Immunogenic Potential of Xenografts.

Tissue antigenicity represents the main limitation for the use of xenografts in clinical practice. To eliminate xenoantigens and avoid graft rejection in human, decellularization is often used to remove all immunoreactive components from the extracellular matrix (ECM). After decellularization, acellular scaffolds are required to be investigated regarding the presence of antigens, but commonly used detection methods solely focus on known xenoantigens such as alpha Gal (Galα1,3-Galβ1-4GlcNAc-R) or major histocompatibility complex-I (MHC-I).

Multiplex recurrence networks.

We have introduced a multiplex recurrence network approach by combining recurrence networks with the multiplex network approach in order to investigate multivariate time series. The potential use of this approach is demonstrated on coupled map lattices and a typical example from palaeobotany research. In both examples, topological changes in the multiplex recurrence networks allow for the detection of regime changes in their dynamics.

Prediction of flow dynamics using point processes.

Describing a time series parsimoniously is the first step to study the underlying dynamics. For a time-discrete system, a generating partition provides a compact description such that a time series and a symbolic sequence are one-to-one. But, for a time-continuous system, such a compact description does not have a solid basis.

See-saw relationship of the Holocene East Asian-Australian summer monsoon.

The East Asian-Indonesian-Australian summer monsoon (EAIASM) links the Earth's hemispheres and provides a heat source that drives global circulation. At seasonal and inter-seasonal timescales, the summer monsoon of one hemisphere is linked via outflows from the winter monsoon of the opposing hemisphere. Long-term phase relationships between the East Asian summer monsoon (EASM) and the Indonesian-Australian summer monsoon (IASM) are poorly understood, raising questions of long-term adjustments to future greenhouse-triggered climate change and whether these changes could 'lock in' possible IASM and EASM phase relationships in a region dependent on monsoonal rainfall.

Tweaking synchronization by connectivity modifications.

Natural and man-made networks often possess locally treelike substructures. Taking such tree networks as our starting point, we show how the addition of links changes the synchronization properties of the network. We focus on two different methods of link addition.

Crisis and Emergency Risk Messaging in Mass Media News Stories: Is the Public Getting the Information They Need to Protect Their Health?

The mass media provide an important channel for delivering crisis and emergency risk information to the public. We conducted a content analysis of 369 newspaper and television broadcast stories covering natural disaster and foodborne outbreak events and coded for seven best practices in crisis and emergency risk messaging. On average, slightly less than two (1.

Serum Levels of sRAGE Are Associated with Body Measurements, but Not Glycemic Parameters in Patients with Prediabetes.

Background: Our aim was to assess serum levels of the soluble receptor for advanced glycation end products (sRAGE) and to examine their association with anthropometric and metabolic parameters in patients with prediabetes and obese controls.

Methods: The two study groups were composed of 42 patients with prediabetes and diabetic neuropathy and 42 age-, gender-, body weight (BW)-, and body mass index (BMI)-matched obese adults as the control group. Prediabetes was diagnosed by the following criteria issued by the American Diabetes Association: impaired fasting glucose [fasting plasma glucose (FPG) level of 100-125 mg/dL], impaired glucose tolerance (2 hr plasma glucose level of 140-199 mg/dL after a 75 grams oral glucose challenge), or a glycated hemoglobin (HbA1C) level of 5.