Publications by authors named "Ernie Lee"
Transfus Med Rev
October 2024
Article Synopsis
- β-thalassemia and sickle cell disease are common genetic blood disorders caused by mutations in the β-globin gene, leading to anemia and requiring treatments like blood transfusions and bone marrow transplants.
- New research is exploring the potential of inducing ε-globin expression, which was previously thought non-inducible postnatally, as a way to improve treatment outcomes for these conditions.
- The review highlights the need for further research into the mechanisms of ε-globin silencing and suggests future drug development initiatives to harness its therapeutic benefits.
J Manag Care Spec Pharm
August 2024
Article Synopsis
- Lupus nephritis (LN) is a serious condition related to systemic lupus erythematosus, with up to 30% of patients progressing to end-stage kidney disease (ESKD), making kidney function preservation critical through early treatment.
- Voclosporin, a recently approved calcineurin inhibitor, has shown promising results in studies AURORA 1 and AURORA 2, demonstrating significant reductions in proteinuria and long-term efficacy in preserving kidney function among LN patients.
- The Institute for Clinical and Economic Review (ICER) assessed the cost-effectiveness of voclosporin, finding it to be cost-effective at around $149,260 per quality-adjusted life-year (QALY), highlighting the
