Publications by authors named "Ernie Ho Yee Ho"
Pharmacol Res Perspect
October 2024
Article Synopsis
- Accurate measurement of drug-target interactions is essential for developing new therapies, but traditional methods may be less reliable when receptors are artificially overexpressed in lab settings.
- The study focuses on the CXCR4 receptor, which is linked to cancer progression, and evaluates the new fluorescently tagged antagonist IS4-FAM as a tool for studying its affinity in natural cancer cell environments.
- IS4-FAM effectively labels CXCR4 in various cancer cell lines and shows competitive behavior with a known CXCR4 antagonist, showcasing its potential as a valuable resource for drug discovery in non-modified cells.
