Publications by authors named "Ernesto Miranda-Morales"
Background: Blood metabolites have emerged as promising candidates in the search for biomarkers for Alzheimer's disease (AD), as evidence shows that various metabolic derangements contribute to neurodegeneration in AD.
Objective: We aim to identify metabolic biomarkers for AD diagnosis.
Methods: We conducted an in-depth analysis of the serum metabolome of AD patients and age, sex-matched cognitively unimpaired older adults using ultra-high-performance liquid chromatography-high resolution mass spectrometry.
Article Synopsis
- Alzheimer's disease (AD) primarily affects older adults and is characterized by complex mechanisms, making current therapies only slightly effective, highlighting the need for better diagnostic tools.
- In this study, researchers examined tRNA-derived RNA fragments (tRFs) in body fluids to see if they were influenced by AD, using advanced sequencing techniques to identify these fragments.
- Findings indicated that the tRF5-ProAGG fragment was notably affected by AD, with its levels in serum correlating to the disease stage, suggesting its potential as a biomarker for diagnosing and understanding AD progression.
Article Synopsis
- The study focuses on how exosomes from Alzheimer's disease (AD) patients contribute to problems with the blood-brain barrier (BBB), particularly affecting the integrity of adherens junction proteins in brain microvascular endothelial cells (BMECs).
- Researchers isolated exosomes from the blood of AD patients and normal controls to investigate their effects, finding that AD exosomes reduced levels of VE-cadherin (a key protein for cell junctions) and weakened BBB integrity.
- Results showed that the damaging effects of AD exosomes on VE-cadherin were linked to their RNA content, and AD brains exhibited lower VE-cadherin levels compared to healthy controls, emphasizing the role of exosomal RNA
Background: Blood-brain barrier (BBB) breakdown is a component of the progression and pathology of Alzheimer's disease (AD). BBB dysfunction is primarily caused by reduced or disorganized tight junction or adherens junction proteins of brain microvascular endothelial cell (BMEC). While there is growing evidence of tight junction disruption in BMECs in AD, the functional role of adherens junctions during BBB dysfunction in AD remains unknown.
View Article and Find Full Text PDFPrecision oncology informed by genomic information has evolved in leaps and bounds over the last decade. Although non-small cell lung cancer (NSCLC) has moved to center-stage as the poster child of precision oncology, multiple targetable genomic alterations have been identified in various cancer types. RET alterations occur in roughly 2% of all human cancers.
View Article and Find Full Text PDFParkinson's disease (PD) is characterized by bradykinesia, resting tremor, rigidity and postural instability as well as early symptoms. Previous studies that evaluated the association between H1/H2 MAPT haplotype and PD were mostly conducted in European populations in which the H1 haplotype was a reported risk factor for PD. Despite those findings, some studies have suggested that the association may be ethnically dependent.
View Article and Find Full Text PDFIt has been 200 years since Parkinson's disease (PD) was first described, yet many aspects of its etiopathogenesis remain unclear. PD is a progressive and complex neurodegenerative disorder caused by genetic and environmental factors including aging, nutrition, pesticides and exposure to heavy metals. DNA methylation may be altered in response to some of these factors; therefore, it is proposed that epigenetic mechanisms, particularly DNA methylation, can have a fundamental role in gene-environment interactions that are related with PD.
View Article and Find Full Text PDF