Publications by authors named "Ernesto H Ramos"
Article Synopsis
- Neuropeptide Y (NPY) and Agouti-related peptide (AgRP) neurons in the hypothalamus promote feeding and reduce energy usage, particularly when exposed to high-fat diets that increase saturated free fatty acids like palmitate.
- Research shows that palmitate and the cytokine TNFα trigger neuroinflammation, which results in heightened expression of feeding-related and inflammatory genes in a specific neuronal cell model (mHypoE-46).
- Treatment with metformin and salicylate was found to effectively manage these gene expression changes, highlighting the significance of timing in treatment approaches, with co-treatment showing positive results in reversing inflammation effects, while preventive combinations were better at stopping mRNA increases caused by neuroinflammation.
Gonadotropin-releasing hormone (GnRH) neurons coordinate reproduction. However, whether GnRH neurons directly sense free fatty acids (FFAs) is unknown. We investigated the individual effects of the FFAs docosahexaenoic acid (DHA), palmitate, palmitoleate, and oleate (100 μM each) on Gnrh mRNA expression in the mHypoA-GnRH/GFP neuronal cell model.
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