Neuroimaging Assessment of Nigrosome 1 with a Multiecho Gre Magnetic Resonance Sequence in the Differentiation Between Parkinsons Disease from Essential Tremor and Healthy Individuals.

Background And Purpose: Parkinsonism is commonly seen in many clinical conditions, and the establishment of its etiology may take many years. The possible development of neuroprotective treatments for Parkinsons disease (PD) in the near future will require correct and early diagnosis. This study aims to analyze the accuracy of a low-cost MRI sequence to differentiate PD from patients with essential tremor (ET) and healthy control (HC) individuals.

Magnetic resonance imaging evaluation of nigrosome 1 and neuromelanin can assist Parkinson's disease diagnosis, but requires an expert neuroradiologist.

Introduction: Parkinson's disease (PD) is the second most common neurodegenerative disease. However, the rate of misdiagnosis remains high, even at specialized movement disorder centers.

Purpose: To assess the accuracy of nigrosome 1 and midbrain neuromelanin evaluation in the diagnosis of PD, and to identify possible differences in diagnostic accuracy between neuroradiologists of different experience levels in analyzing these structures.