Effect of effervescent paracetamol on blood pressure: a crossover randomized clinical trial.

Objective: To evaluate the effect of effervescent paracetamol on office and ambulatory blood pressure (BP) compared with noneffervescent paracetamol in hypertensive patients.

Design: This was a multicenter open crossover randomized clinical trial.

Setting: Primary care centers in Catalonia and the Basque Country.

Evaluation of the relationship between effervescent paracetamol and blood pressure: clinical trial.

Background: Paracetamol's solubility is achieved by adding to the excipient sodium salts, either as bicarbonate, carbonate or citrate. As the relationship between salt and hypertension is well known, due to the sodium content it has raised a hypothesis that may interfere with the control of that risk factor. Therefore, the objective of this study is to evaluate the effect on blood pressure of effervescent paracetamol compared to non-effervescent, in hypertensive patients.