Publications by authors named "Ernest M Hannig"
Article Synopsis
- * The study presents a model of the C-terminal HEAT domain of eIF5, identifying specific binding sites for factors eIF1, eIF2, eIF3, and eIF4G, which are critical for complex assembly.
- * Mutations in these binding areas hinder the proper functioning of the preinitiation complex, affecting gene translation, particularly in the regulation of GCN4 protein synthesis.
The integrity of eukaryotic translation initiation factor (eIF) interactions in ribosomal pre-initiation complexes is critical for the proper regulation of GCN4 mRNA translation in response to amino acid availability. Increased phosphorylation of eIF2 under amino acid starvation conditions leads to a corresponding increase in GCN4 mRNA translation. The carboxyl-terminal domain (CTD) of eIF5 (eIF5-CTD) has been identified as a potential nucleation site for pre-initiation complex assembly.
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