Publications by authors named "Ernest D Lykissa"
Article Synopsis
- The study developed a new anti-methamphetamine vaccine (SMA-TT) using components (tetanus toxoid and aluminum hydroxide) that are safe for human use, to observe its effectiveness in mice.
- Results showed that the vaccine successfully raised anti-methamphetamine antibody levels and reduced drug-conditioned behaviors in mice during testing.
- The vaccine also lowered methamphetamine levels in the brain, indicating its potential for further development as a treatment option for drug addiction in humans.
A morphine conjugate vaccine attenuates the behavioral effects of morphine in rats.
Prog Neuropsychopharmacol Biol Psychiatry
August 2013
Vaccines for opioid dependence may provide a treatment that would reduce or slow the distribution of the drug to brain, thus reducing the drug's reinforcing effects. We tested whether a conjugate vaccine against morphine (keyhole limpet hemocyanin-6-succinylmorphine; KLH-6-SM) administered to rats would produce antibodies and show specificity for morphine or other heroin metabolites. The functional effects of the vaccine were tested with antinociceptive and conditioned place preference (CPP) tests.
View Article and Find Full Text PDF