Stimulated Raman scattering and enhancement mechanisms in alkali metal hydroxide aqueous solutions under laser-induced dynamic pressure.

Stimulated Raman scattering (SRS) in lithium hydroxide-water/heavy water (LiOH-HO/DO) solutions with varying concentrations was investigated under laser-induced high-pressure conditions using an Nd: YAG laser. The spectra revealed a significant enhancement in SRS signals, characterized by the emergence of low-wavenumber Raman peaks and a shift of the main SRS peak of liquid water to lower frequencies, evolving from a single peak to two or three peaks, which suggested the formation of an ice-like structure. Additionally, the normalized SRS intensity was higher than that of pure water.

Injectable alginate-based zwitterionic hydrogels promoting endometrial repair and restoring fertility.

The development of novel therapeutic approaches to facilitate endometrial repair and regeneration while preventing adhesion recurrence is a crucial research objective aimed at enhancing clinical outcomes for women with intrauterine adhesions (IUA). In this study, we introduced an injectable Alg-GMA/PTSB zwitterionic hydrogel, characterized by excellent biocompatibility, anti-protein adsorption properties, and biodegradability. In a rat model, the hydrogel significantly promoted the regeneration and angiogenesis of damaged endometrial tissue, leading to improved recovery of epithelial cells, glands, proliferation, and vascularization.

Extracellular vesicle biomarkers in circulation for colorectal cancer detection: a systematic review and meta-analysis.

We provided an overview which evaluated the diagnostic performance of circulation EV biomarkers for CRC from PubMed, Medline, and Web of Science until 21 August 2022.Weidentified 48 studies that involved 7727 participants and evaluated 162 plasma/serum individual EV biomarkers including 117 RNAs and 45 proteins, as well as 45 EV biomarker panels for CRC detection. 12 studies evaluated the diagnostic performance of EV biomarkers for early CRC.

CCND2 is a prognostic biomarker and correlates with immune infiltration in lung adenocarcinoma.

Background: CCND2 expression influences the growth and proliferation of cancer cells and plays a crucial role in immune response of tumor. However, few studies focused on the correlation between CCND2 and lung adenocarcinoma (LUAD) in terms of prognosis and tumor immune infiltration.

Methods: Original LUAD case data were screened from The Cancer Genome Atlas (TCGA) database.

Extracellular vesicle biomarkers for prostate cancer diagnosis: A systematic review and meta-analysis.

Extracellular vesicle (EV) biomarkers have promising diagnostic and screening capabilities for several cancers, and growing evidence indicates that EV biomarkers can be used as diagnostic markers for prostate cancer (CaP). However, data on the diagnostic accuracy of EV biomarkers for CaP diagnosis are conflicting. We performed a systematic review and meta-analysis, aimed to summarize the diagnostic performance of EV biomarkers for CaP.

Extracellular vesicle biomarkers in circulation for the diagnosis of gastric cancer: A systematic review and meta‑analysis.

The prognosis of a gastric cancer (GC) diagnosis is poor due to the current lack of effective early diagnostic methods. Extracellular vesicle (EV) biomarkers have previously demonstrated strong diagnostic efficiency for certain types of cancer, including pancreatic and lung cancer. The present review aimed to summarize the diagnostic value of circulating EV biomarkers for early stage GC.

Titanium surface-grafted zwitterionic polymers with an anti-polyelectrolyte effect enhances osteogenesis.

Zwitterionic polymers have attracted considerable attention because of their anti-adsorption and unique anti-polyelectrolyte effects and was widely used in surface modification. In this study, zwitterionic copolymers (poly (sulfobetaine methacrylate-co-butyl acrylate) (pSB) coating on the surface of a hydroxylated titanium sheet using surface-initiated atom transfer radical polymerization (SI-ATRP) was successfully constructed. X-ray photoelectron spectroscopy (XPS), Fourier transform infrared spectroscopy (FT-IR) and Water contact angle (WCA) analysis proved the successful preparation of the coating.

Injectable carboxymethyl chitosan-genipin hydrogels encapsulating tea tree oil for wound healing.

Injectable hydrogel is of interesting for wound healing due to it can be used as carriers of bioactive molecules for the reparation of tissues with minimal invasiveness. However, the integration of lipid-soluble substances into hydrogel network is difficult because of the polarity differences. Here, the tea tree oil (TTO) is encapsulated into the hydrogel network via a previous emulsification process, and a tough and antibacterial injectable hydrogel is synthesized by the Schiff base reaction between carboxymethyl chitosan (CMCS) and genipin (GP).

Li-N Interaction Induced Deep Eutectic Gel Polymer Electrolyte for High Performance Lithium-Metal Batteries.

As emerging eutectic mixtures, deep eutectic electrolytes (DEEs) show unique properties for Li-metal batteries (LMBs). However, the limited choice and inferior electrode compatibility hinder their further development in LMBs. Herein, we report a new 1,2-dimethylimidazole (DMIm)-based deep eutectic gel polymer electrolyte induced by Li-N interaction.

Extracellular vesicle biomarkers for pancreatic cancer diagnosis: a systematic review and meta-analysis.

Background: Extracellular vesicle (EV) biomarkers have promising diagnosis and screening capacity for several cancers, but the diagnostic value for pancreatic cancer (PC) is controversial. The aim of our study was to review the diagnostic performance of EV biomarkers for PC.

Methods: We performed a systematic review of PubMed, Medline, and Web Of Science databases from inception to 18 Feb 2022.

Construction and validation of a novel prognostic model for lung squamous cell cancer based on N6-methyladenosine-related genes.

Background: N6-methyladenosine (m6A) is the most prevalent modification in mRNA in biological processes and associated with various malignant tumor initiation and progression. The present study aimed to construct a prognostic risk model based on m6A-related genes (the downstream genes influenced by m6A modulators) for LUSC.

Methods: Based on TCGA, we stratified LUSC patients with and without genetic alteration of m6A modulators into altered and unaltered groups.

Achieving NIR Light-Mediated Tumor-Specific Fenton Reaction-Assisted Oncotherapy by Using Magnetic Nanoclusters.

As an emerging strategy for oncotherapy, Fenton chemistry can efficiently improve the conversion from endogenous HO into highly toxic ·OH in the whole high-performance therapeutic process. Although promising, the efficiency of Fenton reaction in tumor regions is highly limited by the inefficient delivery of Fenton reagents and the restrictive conditions of tumor microenvironment. One promising strategy against the above limitations is to specifically increase the temperature around the tumor regions.

Hemocompatibility of polyzwitterion-modified titanium dioxide nanotubes.

Titanium dioxide nanotubes (TNTs) have attracted increasing interest as implantable materials due to their many desirable properties. However, their blood compatibility remains an issue. In this paper, TNTs of different diameters were modified with two types of zwitterionic polymers, poly(sulfobetaine methacrylate) (pSBMA) and poly(carboxybetaine methacrylate) (pCBMA), which were grafted onto the TNTs using ARGET-ATRP (activators regenerated by electron transfer atom transfer radical polymerization) method.

Identification of prognostic miRNA biomarkers for esophageal cancer based on The Cancer Genome Atlas and Gene Expression Omnibus.

MicroRNAs (miRNAs) in tumor and tumor-adjacent tissues can be effective diagnostic and prognostic markers to monitor tumor occurrence and progression. Despite improvements in the diagnosis and treatment of esophageal cancer (EC), the survival rate is <25%; consequently, more effective EC-specific prognostic biomarkers are urgently needed to design effective treatment regimens. In this study, we focused on identifying independent prognostic miRNA signatures in tumor and tumor-adjacent tissues in EC.

Atypical adult-onset Still's disease with an initial and sole manifestation of liver injury: A case report and review of literature.

Background: Adult-onset Still's disease (AOSD) typically presents with a high spiking fever, polyarthritis, transient maculopapular rash, neutrophilic leukocytosis, and hepatosplenomegaly. It has a wide spectrum of clinical symptoms ranging from mild to severe, with extensive involvement of almost every organ. Although liver involvement in the form of increased hepatic enzymes and bilirubin is common, no AOSD case with liver involvement as the initial manifestation of AOSD has been reported.

Circulating miR-17 as a promising diagnostic biomarker for lung adenocarcinoma: evidence from the Gene Expression Omnibus.

Background: A definitive preoperative diagnosis of lung adenocarcinoma (LUAD) is a clinical challenge. Informative and blood-based microRNAs (miRNAs) may provide new insights on LUAD screening and detection but are limited by suboptimal accuracy.

Methods: The raw expression levels of circulating miR-21, miR-155, miR-210, miR-126, miR-182, and miR-17 in LUAD cases and healthy controls from the Gene Expression Omnibus (GEO) database were obtained and analyzed to identify accurate diagnostic miRNAs biomarkers for LUAD detection.

Phytoestrogens in NAFLD: Potential Mechanisms of Action.

Many studies have shown that estrogen has a protective effect on premenopausal women with metabolic disorders and non-alcoholic fatty liver disease. Estrogen supplements may, at least in theory, prevent the development and progression of NAFLD, while the possibility of inducing cancer limits its application in practice. Phytoestrogen is extracted from plants, whose molecular structure and biological activity are similar to those of mammals' estrogen, therefore, could replace the role of estrogen and prevent the occurrence of adverse reactions to estrogen.

Phytoestrogens and NAFLD: Possible Mechanisms of Action.

Nonalcoholic Fatty Liver Disease (NAFLD) includes a variety of changes including nonalcoholic fatty liver, cirrhosis and Hepatocellular Carcinoma (HCC), which are associated with metabolic disorders and cardiovascular diseases. The pathogenesis of NAFLD is complex and multifactorial. Many studies have shown that estrogen has a protective effect on premenopausal women with metabolic disorders and non-alcoholic fatty liver disease.

lncRNA BCAR4 sponges miR‑370‑3p to promote bladder cancer progression via Wnt signaling.

Accumulating evidence suggests that the aberrant expression of long non‑coding RNAs (lncRNAs) is involved in the initiation, development and metastasis of bladder cancer (BC). Although several differentially expressed lncRNAs have been identified via lncRNA expression profiling of BC tissues, their functions and the molecular mechanisms underlying these functions remain to be fully elucidated. In the present study, elevated levels of lncRNA breast cancer anti‑estrogen receptor 4 (BCAR4) were identified in BC tissues compared with matched healthy tissues.

Circulating microRNAs as promising diagnostic biomarkers for pancreatic cancer: a systematic review.

Pancreatic cancer (PC) is one of the most common forms of malignant tumors and causes of tumor-related death worldwide. The current prognosis of PC still remains poor due to the lack of effective early detection method. Recently, there is strong support that circulating miRNAs can be used as biomarkers for early detection of various cancers, including PC.

Transparent and Scratch-Resistant Antifogging Coatings with Rapid Self-Healing Capability.

Typical antifogging coatings based on hydrophilic polymers are soft and susceptible to mechanical damage. In this paper, an antifogging coating that is both scratch-resistant and self-healing is fabricated by copolymerizing sulfobetaine methacrylate and 2-hydroxyethyl methacrylate in the presence of sulfobetaine-modified silica nanoparticles in one pot. The coating is highly efficient in preventing fog formation at the surface and reducing ice adhesion, and is resistant to fouling by oil and protein, due to the strong hydration ability of the zwitterionic moieties.

Recurrence in unicentric castleman's disease postoperatively: a case report and literature review.

Background: Our case describe a rare recurrence case of Unicentric Castleman's disease (UCD) with hyaline vascular type 14 years after surgery.

Case Presentation: A 35-year-old Chinese female was admitted to hospital with one and half months history chest distress and chest pain. Patient reports a history of thoracic operation for mediastinal mass 14 years ago, and it was diagnosed UCD with hyaline vascular type after postoperative pathological examination.

The Significant Pathways and Genes Underlying the Colon Cancer Treatment by the Traditional Chinese Medicine PHY906.

Background: We attempted to explore the molecular mechanism underlying PHY906 intervention of colon cancer.

Methods: The microarray data of tumors treated by PHY906 and PBS alone were downloaded from the public Gene Expression Omnibus database. The dataset was further analyzed for the differentially expressed genes (DEGs) and their related biological functions were analyzed, followed by function and pathways.

Global correlation analysis for microRNA and gene expression profiles in human obesity.

Obesity is an increasing health problem associated with major adverse consequences for human health. MicroRNAs (miRNAs), small endogenous non-coding RNAs, regulate the expression of genes that play roles in human body via posttranscriptional inhibition. To identify the miRNAs and their target genes involved in obesity, we downloaded the miRNA and gene expression profiles from gene expression omnibus (GEO) database and analyzed the differentially expressed miRNAs (DEMs) and differentially expressed genes (DEGs) in adipose tissues from obese subjects compared to those from non-obese subjects.