Vacuum inversion and securing of distal colonic pseudodiverticula with novel spiked O-rings.

Background: Diverticular disease is increasingly prevalent in Western societies and is associated with significant morbidity.

Objective: Two-stage endoscopic device development for inversion and secured ligation of colonic diverticula; first, human cadaver studies were performed to measure forces required for diverticular inversion; second, a novel set of devices (elastic spiked O-ring with delivery system) was tested in animals.

Design: Prospective, observational study of human cadavers and prospective, interventional study of a porcine model.