Publications by authors named "Erling Tronvik"
Article Synopsis
- - The study aimed to assess the feasibility of self-administering intranasal evaporative cooling for acute migraine relief at home, following previous success in a clinic setting.
- - Conducted in southern Sweden, the trial involved 15 participants with episodic migraine, but only 6 completed the study due to discomfort and ineffective results.
- - Findings indicated that the treatment was largely considered unpleasant and not significantly more effective than existing care methods, leading to the conclusion that it is not a viable option for home use.
Background: A novel technique for injection of OnabotulinumtoxinA (BTA) towards the sphenopalatine ganglion (SPG) has shown promise in refractory chronic migraine (CM) and chronic cluster headache (CCH). Open label safety and efficacy data are presented here.
Methods: Patients with refractory CM or CCH who had received at least one injection and completed headache diaries were included.
Article Synopsis
- The study aimed to analyze migraine medication usage across the entire Norwegian population from 2010 to 2020 using data from the Norwegian Prescription Database.
- A total of 327,904 individuals were identified as migraine medication users, with findings showing a slight increase in prevalence and a notable rise in the use of preventive treatments, particularly among women.
- The research highlights that while overall migraine treatment prevalence is low, triptan overuse is common in women, prompting the need for clinicians to be more proactive in preventing this issue and tailoring treatments effectively.
Background And Methods: In this narrative review, we introduce key artificial intelligence (AI) and machine learning (ML) concepts, aimed at headache clinicians and researchers. Thereafter, we thoroughly review the use of AI in headache, based on a comprehensive literature search across PubMed, Embase and IEEExplore. Finally, we discuss limitations, as well as ethical and political perspectives.
View Article and Find Full Text PDFBackground: Data from some population-based studies have indicated an increased risk of atrial fibrillation (AF) among patients with migraine, particularly among individuals with migraine with aura. The present study aimed to assess the association between primary headache disorders and AF.
Methods: In a population-based 9-year follow-up design, we evaluated the questionnaire-based headache diagnosis, migraine and tension-type headache (TTH) included, collected in the Trøndelag Health Study (HUNT3) conducted in 2006-2008, and the subsequent risk of AF in the period until December 2015.
Article Synopsis
- Researchers developed machine learning models to predict citation counts and the translational impact of headache research, focusing on their inclusion in guidelines or policy documents.
- They analyzed data from 8,600 publications across three headache journals, using various machine learning techniques to classify citation count intervals and assess translational impact.
- The best model achieved an impressive predictive accuracy with bibliometric data being key for citation counts, while a combination of bibliometric data and publication content was most effective for predicting translational impact.
Background: Headache is a prevalent and debilitating symptom following traumatic brain injury (TBI). Large-scale, prospective cohort studies are needed to establish long-term headache prevalence and associated factors after TBI. This study aimed to assess the frequency and severity of headache after TBI and determine whether sociodemographic factors, injury severity characteristics, and pre- and post-injury comorbidities predicted changes in headache frequency and severity during the first 12 months after injury.
View Article and Find Full Text PDFIntroduction: Visual disturbances are the most common symptoms of migraine aura. These symptoms can be described systematically by subdividing them into elementary visual symptoms. Since visual symptoms of migraine aura are not easy to describe verbally, we developed a collection of images illustrating previously reported elementary visual symptoms.
View Article and Find Full Text PDFMigraine headache is highly prevalent and the most common neurologic disorder, affecting one billion people worldwide. It is also the most disabling condition in people under 50, with a huge impact on working ability, family, and social life. Access to effective preventive medication is important and may be considered if the patient has 6 or more migraine days per month, ineffective abortive agents, or disability on 2 or more days per month.
View Article and Find Full Text PDFMigraine or migraine-like symptoms can contribute to a delayed stroke diagnosis. However, migraine with aura is a common stroke mimic and often the basis for acute thrombolytic therapy. It is probably also the reason why many patients are misdiagnosed with a transient ischemic attack.
View Article and Find Full Text PDFAim: Treatment for cluster headache is currently based on a trial-and-error approach. The available preventive treatment is unspecific and based on few and small studies not adhering to modern standards. Therefore, the authors collaborated to discuss acute and preventive treatment in cluster headache, addressing the unmet need of safe and tolerable preventive medication from the perspectives of people with cluster headache and society, headache specialist and cardiologist.
View Article and Find Full Text PDFBackground: It is unknown whether new daily persistent headache (NDPH) is a single disorder or heterogenous group of disorders, and whether it is a unique disorder from chronic migraine and chronic tension-type headache. We describe a large group of patients with primary NDPH, compare its phenotype to transformed chronic daily headache (T-CDH), and use cluster analysis to reveal potential sub-phenotypes in the NDPH group.
Methods: We performed a case-control study using prospectively collected clinical data in patients with primary NDPH and T-CDH (encompassing chronic migraine and chronic tension-type headache).
Objective: The objective of this study was to aggregate data for the first genomewide association study meta-analysis of cluster headache, to identify genetic risk variants, and gain biological insights.
Methods: A total of 4,777 cases (3,348 men and 1,429 women) with clinically diagnosed cluster headache were recruited from 10 European and 1 East Asian cohorts. We first performed an inverse-variance genomewide association meta-analysis of 4,043 cases and 21,729 controls of European ancestry.
Article Synopsis
- The study aimed to assess the effectiveness and safety of injecting onabotulinum toxin A (BTA) into the sphenopalatine ganglion (SPG) for treating persistent idiopathic facial pain (PIFP).
- It involved a cross-over design, comparing the effects of 25 units of BTA against a placebo, with patients tracking their pain intensity over different periods.
- Results showed no significant pain reduction from BTA compared to placebo, though some patients experienced a reduction, and no serious side effects were reported.
Article Synopsis
- - This study investigates the use of machine learning to predict migraine attacks by analyzing headache diary entries and simple physiological data from patients.
- - Eighteen migraine patients completed 388 diary entries and used an app to measure heart rate, skin temperature, and muscle tension, with a focus on creating accurate predictive models for headaches the next day.
- - The best predictive model, utilizing random forest classification, showed moderate success with a score of 0.62 for predicting headaches, suggesting the potential for mobile health apps and wearables to improve migraine forecasting in the future.
Background: Many patients with cluster headache (CH) are inadequately controlled by current treatment options. Non-invasive vagus nerve stimulation (nVNS) is reported to be effective in the management of CH though some studies suggest that it is ineffective.
Objective: To assess the safety and efficacy of nVNS in chronic cluster headache (CCH) patients.
Article Synopsis
- This systematic review examines treatments for chronic migraine patients who experience medication overuse headache, focusing on topiramate, botulinum toxin type A, and human monoclonal antibodies targeting calcitonin gene-related peptide.
- After reviewing 1599 records, 10 studies were included, with 7 providing sufficient data for a meta-analysis, showing botulinum toxin type A reduced headache frequency by an average of 1.92 days per month, while human monoclonal antibodies demonstrated significant positive effects across all measured outcomes.
- No significant differences in adverse effects were found between botulinum toxin type A and a low dose of human monoclonal antibodies versus placebo, and the evidence on topiramate's effectiveness remains inconclusive
Background: Oxygen inhalation aborts cluster headache attacks, and case reports show the effect of continuous positive airway pressure. The aim of this study was to investigate the prophylactic effect of continuous positive airway pressure in chronic cluster headache.
Methods: This was a randomized placebo-controlled triple-blind crossover study using active and sham continuous positive airway pressure treatment for chronic cluster headache.
Importance: The use of spinal cord stimulation for chronic pain after lumbar spine surgery is increasing, yet rigorous evidence of its efficacy is lacking.
Objective: To investigate the efficacy of spinal cord burst stimulation, which involves the placement of an implantable pulse generator connected to electrodes with leads that travel into the epidural space posterior to the spinal cord dorsal columns, in patients with chronic radiculopathy after surgery for degenerative lumbar spine disorders.
Design, Setting, And Participants: This placebo-controlled, crossover, randomized clinical trial in 50 patients was conducted at St Olavs University Hospital in Norway, with study enrollment from September 5, 2018, through April 28, 2021.
Surgery for degenerative cervical myelopathy in patients with rheumatoid arthritis and ankylosing spondylitis: a nationwide registry-based study with patient-reported outcomes.
Acta Neurochir (Wien)
December 2022
Purpose: To compare patient-reported outcomes (PROMs) following surgery for degenerative cervical myelopathy (DCM) among patients with rheumatoid arthritis (RA) or ankylosing spondylitis (AS) versus those without rheumatic diseases.
Methods: Data were obtained from the Norwegian Registry for Spine Surgery. The primary outcome was change in the Neck Disability Index (NDI) at 1 year.
Responsive to treatment individually, chronic migraine remains strikingly resistant collectively, incurring the second-highest population burden of disability worldwide. A heterogeneity of responsiveness, requiring prolonged-currently heuristic-individual evaluation of available treatments, may reflect a diversity of causal mechanisms, or the failure to identify the most important, single causal factor. Distinguishing between these possibilities, now possible through the application of complex modelling to large-scale data, is critical to determine the optimal approach to identify new interventions in migraine and making the best use of existing ones.
View Article and Find Full Text PDFObjective: Migraine is a primary headache disorder with a well-known association with insufficient sleep. However, both the underlying pathophysiology of the disease and the relationship with sleep is still unexplained. In this study, we apply transcranial magnetic stimulation to investigate possible mechanisms of insufficient sleep in migraine.
View Article and Find Full Text PDFBackground: Anatomical and experimental data indicate that onabotulinimtoxin A could be more efficient and cost-effective for treating chronic migraine with injections targeting the cranial sutures, where collaterals from the meninges penetrate the skull.
Methods: A new injection paradigm (FollowTheSutures) was tested for safety, tolerability and feasibility in a Phase II, open-label, non-controlled, single-center pilot study. Ninety units of onabotulinimtoxin A (Botox®), were injected in 18 sites over the area of the cranial sutures.
Article Synopsis
- The study investigates the two-way relationship between headaches (specifically tension-type headache and migraine) and mental health issues like anxiety and depression over an 11-year period.
- Using data from the Trøndelag Health Study, researchers analyzed the risk factors for developing headaches from pre-existing anxiety/depression and vice versa.
- Results showed that higher anxiety and depression scores at the start of the study nearly doubled the risk of later developing migraines, and headaches also increased the risk of anxiety and depression, with a stronger connection observed for migraines compared to tension-type headaches.