Bacteriophage ɸPT1b-Based Hand Sanitizer Gel for Reducing Pathogenic Infection.

Foodborne disease is caused by consuming pathogenic microorganism-contaminated food that generates poisoning. is a bacterium that causes foodborne disease, which is neutralized using gel hand sanitizer containing a bacteriophage with hydroxypropyl methylcellulose (HPMC) and active glycerin ingredients. Phages are viruses that infect bacteria naturally.

Potential bacteriophages to overcome bacterial infection of Alcaligenes faecalis in diabetic ulcer.

Introduction: Diabetes is a non-contagious disease, but it can cause various complications. One of the most common complications of diabetes is diabetic ulcers. Diabetic ulcers are infections that occur in the legs of diabetics due to the destruction of the deepest skin tissue.

Construction of SHERLOCK-based sgRNA for SARS-CoV-2 Diagnostics from Indonesia.

Handling a pandemic requires high sensitivity, high specificity, simple, fast, and flexible tests. How- ever, conventional test methods (RT-PCR and Rapid Antigen) have weaknesses in test efficiency. Specific High sensitivity Enzymatic Reporter un-LOCKing (SHERLOCK), is a new technology that can detect nucleic acids even with limited sample preparation, but with high sensitivity, high spec- ificity, rapidly, and flexibly.

In-silico analysis of recombinant protein vaccines based on the spike protein of Indonesian SARS-CoV-2 through a reverse vaccinology approach.

Objectives: This study aimed to produce a recombinant protein vaccine candidate based on an epitope of spike protein from Indonesian SARS-CoV-2 to provide immunogenicity and protection against future infection.

Methods: A reverse vaccinology approach was used to identify potential vaccine candidates by screening the pathogen's genome through computational analyses.

Results: Epitope vaccine candidates with the amino acid sequence of FKNHTSPDV were selected.

Effect of Phage-Antibiotic Synergism (PAS) in increasing antibiotic inhibition of bacteria caused of foodborne diseases.

Introduction: Food contaminated with pathogenic bacteria is one of the most harmful things that can even threaten human life. Over time, these pathogenic bacteria are increasingly resistant to antibiotics. Continuous use of synthetic preservatives will also have an adverse effect.

Antihyperglycaemic and tissue-repair effects of extract in streptozotocin-induced diabetic mice.

Objectives: In this study, we aimed to investigate the effects of oral administration of (antlion) extract on liver and kidney histology in streptozotocin-induced diabetic mice.

Methods: Twenty-four mice received a single intraperitoneal injection of streptozotocin and were then divided into six groups. Untreated diabetic mice served as the negative control group, and glibenclamide-treated mice served as the positive control group.

Genomic diversity of large-plaque-forming podoviruses infecting the phytopathogen Ralstonia solanacearum.

The genome organization, gene structure, and host range of five podoviruses that infect Ralstonia solanacearum, the causative agent of bacterial wilt disease were characterized. The phages fell into two distinctive groups based on the genome position of the RNA polymerase gene (i.e.

The involvement of the PilQ secretin of type IV pili in phage infection in Ralstonia solanacearum.

PilQ is a member of the secretin family of outer membrane proteins and specifically involved in type IV secretion. Here we report the effects of pilQ mutation in Ralstonia solanacearum on the host physiology including susceptibility to several phage types (Inoviridae, Podoviridae and Myoviridae). With three lines of cells, namely wild type, ΔpilQ and pilQ-complemented cells, the cell surface proteins, twitching motility and sensitivity to phages were compared.