Publications by authors named "Erkio Sugano"
Int J Mol Sci
September 2017
Article Synopsis
- Mitochondrial oxidative stress plays a significant role in developing diabetic cardiomyopathy, and Thioredoxin 2 (Trx2) is a key mitochondrial antioxidant involved in reducing oxidative damage.
- Inhibiting Trx reductase 2 (TrxR2) leads to an increase in reactive oxygen species (ROS) and worsens heart function, while high glucose conditions decrease Trx2 levels in cardiac cells and diabetic rat hearts.
- Overexpressing Trx2 in high glucose-treated cardiac cells helps protect against oxidative damage, improves ATP production, and reduces harmful gene expression linked to heart stress, suggesting that boosting Trx2 could benefit diabetic hearts.
