Cytotoxic and apoptotic effects of 1,2-diborolanes with strong donor substitutes on human cancer cells.

In recent years, boron compounds have become more common as chemotherapy agents against certain types of cancers. Along with the development of boron-based therapeutic agents have come investigations into the various cancers and biochemical and molecular mechanisms affected by boron compounds and the relationships between boron compounds and chemical protection against cancer. In this preliminary study, the effects of new 1,2-N-substituted-1,2-diborolane derivatives on types of breast and liver cancers were examined for the first time.

Neutral cyclic sp-sp and sp-sp diboranes from ,'-dicyclohexylcarbodiimide insertion into 1,2-dichlorodiboranes(4).

We report the synthesis and structural characterization of new neutral cyclic sp2-sp3 and sp3-sp3 diboranes from the reaction of N,N'-dicyclohexylcarbodiimide with 1,2-dichlorodiboranes(4) at room temperature. The present study is the first example of an insertion reaction of carbodiimide into diborane(4).

Coordinative trapping of the boron β-diketiminato system [B(NMesCMe)2CH] via metal-templated synthesis.

A metal templated synthetic approach gives access to [Cp*Fe(CO)(2){B(NMesCMe)(2)CH}][BAr(f)(4)], and represents the first example of coordinative trapping of the elusive [B(NRCMe)(2)CH] fragment.

A practical synthesis of novel α-dibromoalkyl- and trimethylsilylmethyl-aminoboranes and derivatives.

Addition of LDA to a mixture of trimethylborate and dibromomethane in THF at a temperature of -78°C leads to the formation of dibromomethyllithium and its capture by borate ester. ClB(OMe)(2) converts the resulting borate salt to dimethoxy(dibromomethyl)borane 2. N,N-Dimethylamino(methoxy)(dibromomethyl)borane 3 and N,N-bis(dimethylamino)(dibromomethyl)borane 4 were prepared by an amination reaction between N,N-dimethylaminotrimethylsilane and dimethoxy(dibromomethyl)borane 2.