Physicochemical Characteristics and the Scale Inhibition Effect of Air Nanobubbles (A-NBs) in a Circulating Cooling Water System.

Air nanobubbles (A-NBs) in a circulating cooling water system have not been investigated, although their role is significant. In this paper, the influences of the contents of main salts and other parameters on the physicochemical characteristics and scale inhibition performance of A-NBs in circulating cooling water were investigated and the scale inhibition mechanism of A-NBs in a simulated circulating cooling water system was explored. A-NBs realized a higher scale inhibition rate of 90%, which was higher than that of 1-hydroxyethane-1,1-diphosphonic acid (40%), and A-NBs stably existed for more than 5 days in the complex water environment.

Introduction of a Cys360Tyr Mutation in ANO5 Creates a Mouse Model for Gnathodiaphyseal Dysplasia.

Gnathodiaphyseal dysplasia (GDD) is a rare autosomal dominant genetic disease characterized by the osteosclerosis of tubular bones and the formation of cemento-osseous lesions in mandibles. Although genetic mutations for GDD have been identified in the ANO5/TMEM16E gene, the cellular and molecular mechanisms behind the pathogenesis of GDD remain unclear. Here, we generated the first knock-in mouse model for GDD with the expression of human mutation p.

Nuclear factor (NF)-κB p65 regulates differentiation of human and mouse lung fibroblasts mediated by TGF-β.

Aims: Nuclear factor (NF)-κB signaling pathway contributes to the pathogenesis of lung fibrosis. However, the expression and roles of NF-κB p65 subunit in fibroblasts under fibrotic conditions have not been studied. We checked the expression of p65 in lung tissue and fibroblasts from bleomycin (BLM) challenged mice and investigated the roles of p65 in human lung fibroblast differentiation during transforming growth factor β (TGF-β) challenge.

[Association of methylenetetrahydrofolate reductase A1298C polymorphisms with non-syndromic cleft lip with or without cleft palate].

Objective: To investigate the association between a polymorphism of methylenetetrahydrofolate reductase with Non-syndromic cleft lip with or without cleft palate (NSCL/P) in Chinese population.

Methods: The polymerase chain reaction (PCR)-based restriction fragment length polymorphism (RFLP) technique was used to detect a single nucleotide polymorphism (SNP), rs1801131, at the methylenetetrahydrofolate reductase (MTHFR) gene in both 158 patients with NSCL/P and 192 healthy individuals. The Hardy-Weinberg equilibrium for genotypic distributions was estimated by the goodness-of-fit test.

BHMT gene polymorphisms as risk factors for cleft lip and cleft palate in a Chinese population.

Objective: Convincing evidence suggests a link between increased risk of nonsyndromic cleft lip with or without cleft palate (NSCL/P) and low intake of folic acid by the mother during pregnancy. The present study was designed to explore if genetic variation in the betaine-homocysteine methyltransferase (BHMT) gene contributes to NSCL/P.

Methods: DNA was obtained from 166 individuals with NSCL/P and 285 healthy subjects.