Poroviscoelastic relaxations and rate-dependent adhesion in gelatin.

Hydrogels, polymeric networks swollen with water, exhibit time/rate-dependent adhesion due to their poroviscoleastic constitution. In this study, we conducted probe-tack experiments on gelatin and investigated the influence of dwelling times and unloading rates on pull-off forces and work of adhesion. We utilized contact imaging to monitor separation kinematics and interfacial crack velocities.

Correlation of mineral density and elastic modulus of dog dentin using μ-CT and nanoindentation.

This study sought to 1) investigate the spatial distribution of mineral density of dog dentin using µ-CT and 2) characterize the relationship between the elastic modulus and mineral density of dog dentin using nanoindentation and µ-CT. Maxillary canine teeth of 10 mature dogs were scanned with a µ-CT then sectioned in the transverse and vertical planes and tested using nanoindentation. Spatial distribution of mineral density and elastic modulus was quantified.

Effect of osmolarity and displacement rate on cartilage microfracture clusters failure into two regimes.

Articular cartilage is a poroviscoelastic (PVE) material with remarkable resistance to fracture and fatigue failure. Cartilage failure mechanisms and material properties that govern failure are incompletely understood. Because cartilage is partially comprised of negatively charged glycosaminoglycans, altering solvent osmolarity can influence PVE relaxations.

Structure-function relationships in dog dentin.

Investigations into teeth mechanical properties provide insight into physiological functions and pathological changes. This study sought to 1) quantify the spatial distribution of elastic modulus, hardness and the microstructural features of dog dentin and to 2) investigate quantitative relationships between the mechanical properties and the complex microstructure of dog dentin. Maxillary canine teeth of 10 mature dogs were sectioned in the transverse and vertical planes, then tested using nanoindentation and scanning electron microscopy (SEM).

Data-driven nonlinear model reduction to spectral submanifolds in mechanical systems.

While data-driven model reduction techniques are well-established for linearizable mechanical systems, general approaches to reducing nonlinearizable systems with multiple coexisting steady states have been unavailable. In this paper, we review such a data-driven nonlinear model reduction methodology based on spectral submanifolds. As input, this approach takes observations of unforced nonlinear oscillations to construct normal forms of the dynamics reduced to very low-dimensional invariant manifolds.

Effects of solvent osmolarity and viscosity on cartilage energy dissipation under high-frequency loading.

Articular cartilage is a spatially heterogeneous, dissipative biological hydrogel with a high fluid volume fraction. Although energy dissipation is important in the context of delaying cartilage damage, the dynamic behavior of articular cartilage equilibrated in media of varied osmolarity and viscosity is not widely understood. This study investigated the mechanical behaviors of cartilage when equilibrated to media of varying osmolarity and viscosity.

Microindentation Technique to Create Localized Cartilage Microfractures.

Articular cartilage is a multiphasic, anisotropic, and heterogeneous material. Although cartilage possesses excellent mechanical and biological properties, it can undergo mechanical damage, resulting in osteoarthritis. Thus, it is important to understand the microscale failure behavior of cartilage in both basic science and clinical contexts.

Brain-mimicking phantom for biomechanical validation of motion sensitive MR imaging techniques.

Motion sensitive MR imaging techniques allow for the non-invasive evaluation of biological tissues by using different excitation schemes, including physiological/intrinsic motions caused by cardiac pulsation or respiration, and vibrations caused by an external actuator. The mechanical biomarkers extracted through these imaging techniques have been shown to hold diagnostic value for various neurological disorders and conditions. Amplified MRI (aMRI), a cardiac gated imaging technique, can help track and quantify low frequency intrinsic motion of the brain.

Relaxation capacity of cartilage is a critical factor in rate- and integrity-dependent fracture.

Articular cartilage heals poorly but experiences mechanically induced damage across a broad range of loading rates and matrix integrity. Because loading rates and matrix integrity affect cartilage mechanical responses due to poroviscoelastic relaxation mechanisms, their effects on cartilage failure are important for assessing and preventing failure. This paper investigated rate- and integrity-dependent crack nucleation in cartilage from pre- to post-relaxation timescales.

Glycosaminoglycan depletion increases energy dissipation in articular cartilage under high-frequency loading.

High-frequency material behavior of cartilage at macroscopic lengths is not widely understood, despite a wide range of frequencies and contact lengths experienced in vivo. For example, cartilage at different stages of matrix integrity can experience high-frequency loading during traumatic impact, making high-frequency behavior relevant in the context of structural failure. Therefore, this study examined macroscopic dissipative and mechanical responses of intact and glycosaminoglycan (GAG)-depleted cartilage under previously unexplored high-frequency loading.

Rate-dependent adhesion of cartilage and its relation to relaxation mechanisms.

Cartilage adhesion has been found to play an important role in friction responses in the boundary lubrication regime, but its underlying mechanisms have only been partially understood. This study investigates the rate dependence of adhesion from pre-to post-relaxation timescales of cartilage and its possible relation to relaxation responses of the tissue. Adhesion tests on cartilage were performed to obtain rate-dependent cartilage adhesion from relaxed to unrelaxed states and corresponding relaxation responses.

Rate-dependent crack nucleation in cartilage under microindentation.

This study investigates rate-dependent crack nucleation in cartilage under microindentation using a poroviscoelastic framework and nano/microscopic images. Localized crack failure was induced at known locations and at different loading rates via microindentation with an axisymmetric sphero-conical indenter. Finite element (FE) modeling was used to reproduce results of microindentation tests within a poroviscoelastic framework.

Effect of relaxation-dependent adhesion on pre-sliding response of cartilage.

Possible links between adhesive properties and the pre-sliding (static) friction response of cartilage are not fully understood in the literature. The aims of this study are to investigate the relation between adhesion and relaxation time in articular cartilage, and the effect of relaxation-dependent adhesion on the pre-sliding response of cartilage. Adhesion tests were performed to evaluate the work of adhesion of cartilage at different relaxation times.

Uncoupled poroelastic and intrinsic viscoelastic dissipation in cartilage.

This paper studies uncoupled poroelastic (flow-dependent) and intrinsic viscoelastic (flow-independent) energy dissipation mechanisms via their dependence on characteristic lengths to understand the root of cartilage's broadband dissipation behavior. Phase shift and dynamic modulus were measured from dynamic microindentation tests conducted on hydrated cartilage at different contact radii, as well as on dehydrated cartilage. Cartilage weight and thickness were recorded during dehydration.

A rigorous dynamical-systems-based analysis of the self-stabilizing influence of muscles.

In this paper, dynamical systems analysis and optimization tools are used to investigate the local dynamic stability of periodic task-related motions of simple models of the lower-body musculoskeletal apparatus and to seek parameter values guaranteeing their stability. Several muscle models incorporating various active and passive elements are included and the notion of self-stabilization of the rigid-body dynamics through the imposition of musclelike actuation is investigated. It is found that self-stabilization depends both on muscle architecture and configuration as well as the properties of the reference motion.