Ocular Bacterial Infections: A Ten-Year Survey and Review of Causative Organisms Based on the Oklahoma Experience.

Ocular infections can be medical emergencies that result in permanent visual impairment or blindness and loss of quality of life. Bacteria are a major cause of ocular infections. Effective treatment of ocular infections requires knowledge of which bacteria are the likely cause of the infection.

C-X-C Chemokines Influence Intraocular Inflammation During Bacillus Endophthalmitis.

Purpose: The purpose of this study was to explore the C-X-C chemokines CXCL2 and CXCL10 as potential anti-inflammatory targets for Bacillus endophthalmitis.

Methods: Bacillus endophthalmitis was induced in C57BL/6J, CXCL2-/-, and CXCL10-/- mice. At specific times postinfection, eyes were analyzed for Bacillus, retinal function, and inflammation.

Immune Inhibitor A Metalloproteases Contribute to Virulence in Endophthalmitis.

Endophthalmitis is a devastating infection that can cause blindness. Over half of endophthalmitis cases result in significant loss of useful vision. produces many virulence factors that may contribute to retinal damage and robust inflammation.

Innate Immune Interference Attenuates Inflammation In Bacillus Endophthalmitis.

Purpose: To explore the consequences of innate interference on intraocular inflammatory responses during Bacillus endophthalmitis.

Methods: Bacillus endophthalmitis was induced in mice. Innate immune pathway activation was interfered by injecting S layer protein-deficient (∆slpA) B.

The cereus matter of Bacillus endophthalmitis.

Bacillus cereus (B. cereus) endophthalmitis is a devastating intraocular infection primarily associated with post-traumatic injuries. The majority of these infections result in substantial vision loss, if not loss of the eye itself, within 12-48 h.

A Pyrrhic Victory: The PMN Response to Ocular Bacterial Infections.

Some tissues of the eye are susceptible to damage due to their exposure to the outside environment and inability to regenerate. Immune privilege, although beneficial to the eye in terms of homeostasis and protection, can be harmful when breached or when an aberrant response occurs in the face of challenge. In this review, we highlight the role of the PMN (polymorphonuclear leukocyte) in different bacterial ocular infections that invade the immune privileged eye at the anterior and posterior segments: keratitis, conjunctivitis, uveitis, and endophthalmitis.