Managing primary open-angle glaucoma in the setting of suboptimal surgical outcomes in the fellow eye.

A 62-year-old woman with mild myopia presented to her local optometrist for a routine examination and was found to have intraocular pressure (IOP) of 30 mm Hg in both eyes and cupped nerves. She had a family history of glaucoma in her father. She was started on latanoprost in both eyes and was referred for a glaucoma evaluation.

Cost comparison of different treatment approaches of dacryocystitis and dacrocystocele.

Purpose: Congenital dacrocystocele with potential for dacryocystitis are common ophthalmic findings in children. There are multiple surgical approaches to open the mucocele. In this study, we look at the financial impact of these different approaches.

Retinal artery occlusion followed by contralateral amaurosis fugax in association with eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome).

Purpose: To describe two cases of retinal artery occlusion followed by contralateral amaurosis fugax associated with eosinophilic granulomatosis with polyangiitis (EGPA, formerly known as Churg-Strauss syndrome).

Observations: Case 1 is a 57 year-old male who presented with transient vision loss in the right eye two weeks after a cilioretinal artery occlusion in the left eye. Evaluation eventually led to a diagnosis of EGPA.

Rotary Chop: A New Technique for Teaching Chop and Tackling Mature Cataracts.

Introduction: Here we describe a new cataract chop technique that is most valuable for two groups of ophthalmologists: (1) experienced surgeons encountering challenging nuclear fragmentation due to mature cataracts or zonulopathies, and (2) inexperienced surgeons wishing to develop skills necessary for chopping techniques.

Methods: We have termed this new method "rotary chop," since the partial thickness pilot holes created by the phacoemulsification (phaco) tip around the periphery of the nucleus produce a rotary phone dial appearance on the surface of the cataract. By creating these pilot holes, the surgeon is able to easily place the chopper deep into the body of the nucleus, avoiding the need to apply vertical piercing force to the nucleus.

Refractive outcomes among glaucoma patients undergoing phacoemulsification cataract extraction with and without Kahook Dual Blade goniotomy.

Background: Glaucoma patients undergoing phacoemulsification alone have a higher rate of refractive surprise compared to patients without glaucoma. This risk is further increased with combined filtering procedures. Indeed, there are few and conflicting reports on the effect of combined phacoemulsification and micro-invasive glaucoma surgery (MIGS).

Outcomes of Kahook Dual Blade Goniotomy with and without Phacoemulsification Cataract Extraction.

Purpose: To determine the effectiveness and safety of Kahook Dual Blade (KDB) goniotomy in reducing intraocular pressure (IOP) and medication need in glaucoma patients when combined with phacoemulsification or as a standalone procedure.

Design: Retrospective study.

Participants: A total of 197 eyes from 143 patients were reviewed.

An optimized lactate dehydrogenase release assay for screening of drug candidates in neuroscience.

Introduction: Quantification of lactate dehydrogenase (LDH) release is a widely accepted assay for the quantitative determination of cell viability and late-stage apoptosis. Major disadvantages of commercially available LDH assay kits include proprietary formulations, limited options for optimization and high cost, all resulting in limited reproducibility in research applications. Here, we describe a novel, custom LDH assay suitable in the context of plate reader-based screening of drug candidates for glioprotection, but with wide applicability to other cell types and experimental paradigms.