Publications by authors named "Erin Resch"
Article Synopsis
- The study reviewed six pediatric osteosarcoma patients with brain metastases at Johns Hopkins Hospital, revealing a grim median survival of just 2.5 months post-diagnosis.
- Despite various treatments like chemotherapy, surgery, and radiation, most outcomes were fatal, although one patient showed a remarkable 13-month survival with a combination treatment, suggesting the potential of multimodal therapies.
- The findings stress the importance of careful monitoring for neurological symptoms and highlight the need for further research into new treatment strategies and the biology of metastasis to improve patient outcomes.
J Cancer Res Clin Oncol
March 2024
Article Synopsis
- CIC-rearranged sarcomas are aggressive tumors that lead to poor survival rates, quick development of drug resistance, and high metastasis, prompting a need for better understanding of their management and outcomes.
- A study at Johns Hopkins Hospital analyzed the cases of ten patients aged 10 to 67, revealing varied clinical courses, with some undergoing intensive treatments while others had prolonged disease-free survival without systemic therapy.
- Overall survival averaged 22.1 months and progression-free survival averaged 16.7 months, highlighting diverse outcomes and emphasizing the importance of understanding individual tumor biology for better patient care.
Article Synopsis
- The formation of complex tissues from simple epithelial sheets involves gene regulatory hierarchies that create distinct cell fates and rely on interactions between adjacent territories.
- Cells at territorial boundaries maintain separation not just through adhesion differences but also through mechanical asymmetries, particularly in cell properties like tension and structure.
- In the study of Drosophila leg development, it was found that the boundary between pretarsus and tarsus shows alignment and increased mechanical tension, highlighting the importance of Rho Kinase and Myosin II in maintaining this developmental boundary.
