Publications by authors named "Erin P Bilgili"
Article Synopsis
- - Nirmatrelvir/ritonavir is an important COVID-19 treatment for outpatient settings, but it can lead to dangerous interactions with tacrolimus in transplant patients, potentially causing toxicity.
- - In a case series of 5 transplant recipients, they experienced high tacrolimus levels and toxicity after taking nirmatrelvir/ritonavir, leading to the temporary discontinuation of both drugs.
- - The introduction of phenytoin helped lower tacrolimus levels effectively, suggesting it could be a viable strategy for managing this issue in similar patients.
Background: Historically, groups that are most susceptible to health and healthcare disparities have been underrepresented in medical research. It is imperative to explore approaches that can facilitate the recruitment of underrepresented individuals into research studies.
Methods: Two approaches, hospital and community-based recruitment (CBR), were developed and implemented over 36 months to study the genetics of hereditary breast cancer and associated cancers in Alabama, a medically underserved state with double the national percentage of self-identifying African Americans, establishing the Alabama Hereditary Cancer Cohort.
Inherited genetic risk factors contribute toward breast cancer (BC) onset. BC risk variants can be divided into three categories of penetrance (high, moderate, and low) that reflect the probability of developing the disease. Traditional BC susceptibility gene discovery approaches that searched for high- and moderate-risk variants in familial BC cases have had limited success; to date, these risk variants explain only ∼30% of familial BC cases.
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