Setmelanotide: A Novel Targeted Treatment for Monogenic Obesity.

To review clinical data regarding the newly approved drug setmelanotide, an injectable melanocortin 4 receptor (MC4R) agonist, for chronic weight management in adults and children aged 6 years and older with monogenic obesity. A literature review was performed by searching MEDLINE, SCOPUS, and EMBASE for all relevant English-language articles published between January 1, 1996, and November 30, 2021, using search terms obesity, setmelanotide, Imcivree, and MC4R agonist. This review included two phase 2, two phase 3, and one ongoing clinical trial evaluating the efficacy and/or safety of setmelanotide.

Evaluation of Provider Implementation of the 2019 American College of Cardiology and American Heart Association Aspirin for Primary Prevention Guideline Recommendations for Older People.

Retrospective chart review study using electronic medical record data from Inova Health System patients. All cardiology, endocrinology, and primary care outpatient clinics operated by Inova Medical Group (IMG) in Northern Virginia. Participants included were 70 years of age or older and taking aspirin 81 mg as of April 1, 2019.

Herpes zoster and vaccination: a clinical review.

Purpose: Herpes zoster, herpes zoster vaccine, and the cost-effectiveness of the vaccine are reviewed.

Summary: Herpes zoster infection is estimated to affect one in three people during their lifetime. Two thirds of people who develop this disease are over age 60 years.

Carbamazepine-induced hyperammonemia.

Purpose: A case of carbamazepine-induced hyperammonemia is presented.

Summary: A 26-year-old man with bipolar disorder, seizures, and mild mental retardation secondary to a traumatic brain injury began treatment with carbamazepine for aggression and seizure control. After three weeks of carbamazepine therapy, the patient arrived at the emergency department (ED) with severe agitation and aggressive behavior.