Social-emotional screening for infants and toddlers in primary care.

Background And Objectives: Recommendations in pediatrics call for general developmental screening of young children; however, research suggests social-emotional development, in particular, is important as an initial indicator of general well-being versus risk. We aim to describe a program designed to identify the social-emotional status of young children in the pediatric setting by using the Ages and Stages Questionnaires: Social-Emotional (ASQ:SE) as a universal screening tool, and to assess the effect of interventions by a colocated psychologist on changes in ASQ:SE scores over time.

Methods: In a prospective cohort design we analyzed scores on ASQ:SE surveys completed on children 6 to 36 months of age, to determine if children were at risk for problems in social-emotional development.

The child behavior checklist PTSD scale: screening for PTSD in young children with high exposure to trauma.

The objective of this study was to examine the validity of the Child Behavior Checklist (CBCL) Posttraumatic Stress Disorder (PTSD) subscale to screen for PTSD in children attending an inner-city early childhood mental health center. Using various measures, we assessed 51 preschool-age children with high exposure to trauma receiving outpatient child-parent psychotherapy for PTSD. We compared 15 items on the CBCL, a proposed subscale indicative of PTSD, to the UCLA-PTSD Index and to clinical diagnosis based on the Diagnostic and Statistical Manual of Mental Disorders (4th ed.

Huntingtin interacting protein 14 is an oncogenic human protein: palmitoyl acyltransferase.

Protein palmitoyltransferases (PATs) represent an exciting new target for anticancer drug design due to their pivotal roles in the subcellular localization of a number of oncogenes. We show that the Huntingtin interacting protein 14 (HIP14) is a PAT with a preference for the farnesyl-dependent palmitoylation motif found in H- and N-RAS. Characterization of HIP14 in mouse cells has revealed that it has the ability to induce colony formation in cell culture, anchorage-independent growth, and tumors in mice.

Radial glia produce and align the ligand fibronectin during neuronal migration in the developing chick brain.

We demonstrated previously that alpha8beta1 integrin regulates the migration and survival of immature neurons during development of the chicken optic tectum; however, the potential extracellular ligand was unknown. We used immunohistochemistry to determine if several potential ligands (fibronectin, tenascin, vitronectin, and osteopontin) were expressed during neuronal migration along radial glia (RG). Fibronectin was localized in a pattern relevant to radial migration and survival of neurons; it was present before and during neuronal migration and appeared oriented along RG fibers by conventional fluorescence microscopy.