Publications by authors named "Erin M Faight"
Pulmonary arterial hypertension (PAH) is a rare disease characterized by significant vascular remodeling within the lung. Clinical computed tomography (CT) scans are routinely used to aid in PAH diagnosis. Animal models, including the Sugen-hypoxic rat model (SU/hyp), of PAH closely mimic human PAH development.
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- Pulmonary arterial hypertension (PAH) is a rare disease featuring significant changes in blood vessel structure, which may be linked to inflammation caused by obesity-related fat deposits.
- The study utilized advanced microCT imaging and proteomics to examine lung vascular remodeling and adipose tissue dysfunction in rats exposed to a specific treatment (Sugen 5416) and hypoxia.
- Key findings indicate notable changes in lung vasculature and increased levels of proteins associated with fat dysfunction (C3 and FABP4) in the heart adipose of the treated rats, suggesting a connection between vascular issues and fat tissue impairment in PAH.