Comprehensive Analysis of Large Sets of Age-Related Physiological Indicators Reveals Rapid Aging around the Age of 55 Years.

Background: While many studies show a correlation between chronological age and physiological indicators, the nature of this correlation is not fully understood.

Objective: To perform a comprehensive analysis of the correlation between chronological age and age-related physiological indicators.

Method: Physiological aging scores were deduced using principal component analysis from a large dataset of 1,227 variables measured in a cohort of 4,796 human subjects, and the correlation between the physiological aging scores and chronological age was assessed.