A nurse-driven penicillin allergy risk score in the preoperative setting was associated with increased cefazolin use perioperatively.

Study Objective: To characterize and assess the effects of a preoperative, nurse-driven penicillin allergy risk stratification tool on rates of perioperative cefazolin and second-line antibiotic use.

Design: Quasi-experimental quality improvement study of penicillin-allergic surgical patients undergoing procedures for which cefazolin is indicated.

Setting: Outpatient Perioperative Care Clinic (PCC) for preoperative surgical patients at a tertiary care center.