Publications by authors named "Erin L Buchanan"
Article Synopsis
- SAMHD1, a protein with nucleotidase activity, restricts HIV-1 in myeloid cells by depleting free nucleotides, thereby inhibiting reverse transcription; however, the Vpx protein from HIV-2 and some SIVs can counteract SAMHD1's effects.
- Type I interferons can enhance the transcription of SAMHD1, with observed increases during the acute phase of SIV infection in the CNS, although the levels decrease during quieter phases but generally remain elevated post-infection.
- In vitro studies show that SAMHD1 is highly expressed in macaque astrocytes and is further induced by interferon, suggesting a potential role in restricting retroviruses in
miRNAs and SAMHD1 regulation in vitro and in a model of HIV CNS disease.
J Neuroinflammation
September 2015
Pilakka-Kanthikeel et al. recently reported higher levels of the retroviral restriction factor sterile alpha motif and histidine/aspartic acid domain-containing protein 1 (SAMHD1) in astrocytes than in microglia, suggesting that SAMHD1 levels might explain in part the relatively refractory nature of astrocytes to retroviral replication. These findings are consistent with our studies of simian and human immunodeficiency virus infection of astrocytes and macrophages.
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