Publications by authors named "Erin J Flanagan"
Article Synopsis
- Many cancer treatments are exploring genetic features for therapy, but targeting tissue-level characteristics of the tumor environment can also be effective.
- The study focuses on using low oxygen conditions and inhibition of nitric oxide synthase (NOS) to enhance the effectiveness of the hypoxic cytotoxin tirapazamine (TPZ) against tumor vasculature.
- Results show that combining TPZ with NOS inhibitors or low oxygen can lead to more tumor cell death and reduced tumor growth, particularly in tumors lacking strong vascular structures, indicating a new approach for targeting cancer through hypoxia-activated drugs.
