Publications by authors named "Erin D Michos"
Article Synopsis
- * It involved 746 postmenopausal women and tracked incidents of HF over a median period of 17.8 years, revealing that early menopause significantly increased HF risk, even after accounting for various cardiovascular factors.
- * Adiponectin, one of the adipokines, was found to be independently associated with HF risk, while leptin and resistin showed no significant correlation.
Background: Asian individuals are among the highest immigrant group to the United States and at particularly high risk of gestational diabetes, which is associated with long-term maternal cardiovascular disease. Limited data are available on the association of prepregnancy cardiometabolic risk factors with gestational diabetes among Asian American subjects.
Objectives: This study sought to determine the association of prepregnancy hypertension and body mass index (BMI) among Asian ancestry subgroups and by maternal nativity.
Background: Vital exhaustion, defined as excessive fatigue, demoralization, and irritability due to chronic stress, is independently associated with cardiovascular disease (CVD).
Objectives: The purpose of this study was to examine the association of vital exhaustion with biomarkers associated with CVD risk in the ARIC (Atherosclerosis Risk In Communities) study.
Methods: We examined the cross-sectional association of vital exhaustion (assessed using the Maastricht Vital Exhaustion Questionnaire [MVEQ]) with cardiac biomarker (high-sensitivity troponin T [hs-TnT], N-terminal pro-B-type natriuretic peptide [NT-proBNP]) and high-sensitivity C-reactive protein (hs-CRP) levels in 11,542 ARIC study participants without CVD at ARIC visit 2 using multivariable logistic and linear regression models.
Hypertension is among the most prevalent diagnoses across the world and increases the risk of many serious health problems, such as stroke, heart disease, and kidney disease. Pharmacological approaches to treat hypertension are often required and reduce blood pressure through mechanisms such as vasodilation, inhibition of the renin-angiotensin-aldosterone pathway, and increased urine output to reduce blood volume, among other mechanisms. Further research is ongoing to find novel pathways and mechanisms to treat hypertension, which we summarize in this review.
View Article and Find Full Text PDFBackground: Work-related stress is a psychosocial risk factor linked to a higher risk of cardiovascular disease. However, the association between work-related stress and cardiovascular health (CVH) is not well established. We estimated the association between work-related stress and CVH in a multiethnic sample of adults free of cardiovascular disease at baseline.
View Article and Find Full Text PDFArticle Synopsis
- Prepregnancy diabetes and obesity are significant risk factors for hypertensive disorders of pregnancy (HDPs), with 7% of birthing individuals in a study experiencing HDP.
- Among different racial and ethnic groups, HDP was most prevalent in American Indian and Alaska Native individuals, while diabetes and obesity showed the strongest associations with HDPs in Native Hawaiian and Other Pacific Islander and Asian individuals, respectively.
- The study found that diabetes and obesity account for notable population attributable fractions of HDPs, emphasizing the need for targeted interventions, especially among vulnerable populations such as Native Hawaiian and Other Pacific Islander individuals.
Associations of Hypertension and Orthostatic Hypotension With Subclinical Cardiovascular Disease.
J Gerontol A Biol Sci Med Sci
November 2024
Background: Orthostatic hypotension is associated with cardiovascular disease. It remains unclear if low standing blood pressure or high seated blood pressure is responsible for this association. We compared associations of orthostatic hypotension and hypertension with high-sensitivity cardiac troponin I and N-terminal pro-B-type natriuretic peptide.
View Article and Find Full Text PDFBackground: The metabolic syndrome phenotype of individuals with obesity is characterized by elevated levels of triglyceride-rich lipoproteins and remnant particles, which have been shown to be significantly atherogenic. Understanding the association between adipokines, endogenous hormones produced by adipose tissue, and remnant cholesterol (RC) would give insight into the link between obesity and atherosclerotic cardiovascular disease.
Methods And Results: We studied 1791 MESA (Multi-Ethnic Study of Atherosclerosis) participants who took part in an ancillary study on body composition with adipokine levels measured (leptin, adiponectin, and resistin) at either visit 2 or visit 3.
Article Synopsis
- The study investigated how weight loss affects sex hormone levels in individuals with type 2 diabetes (T2D), focusing on sex differences in hormone response.
- It included 850 postmenopausal women and 890 men, measuring hormones like testosterone and estradiol and observing the impact of an intensive lifestyle intervention (ILI) over time.
- Results showed that ILI led to significant hormone level changes in both sexes, with women experiencing decreases in estradiol and testosterone while men saw increases in testosterone, highlighting the importance of considering these hormonal shifts in relation to health risks.
Objectives: The Life's Simple 7 score (LS7) promotes cardiovascular health (CVH). Despite this, some with optimal LS7 develop cardiovascular disease (CVD), while others with poor CVH do not, termed the "CVH paradox." This paper explores pathways explaining this paradox.
View Article and Find Full Text PDFBackground: Gestational diabetes mellitus (GDM) is associated with increased long-term risk of cardiovascular disease but the cardiovascular structural and functional changes that contribute to risk are not well understood.
Objectives: The purpose of this study was to determine whether GDM is associated with adverse cardiac remodeling and endothelial dysfunction a decade after delivery, independent of type 2 diabetes.
Methods: Women with deliveries between 2008 and 2009 were initially selected from a prospective clinical cohort.
Article Synopsis
Background: Disparities in acute myocardial infarction (AMI)-related outcomes have been reported before the COVID-19 pandemic. We studied in-hospital outcomes of AMI across demographic groups in the United States during the early COVID-19 pandemic.
Methods: The National Inpatient Sample (NIS) database was queried for 2020 to identify AMI-related hospitalizations based on appropriate ICD-10-CM codes categorized by sex, race, and hospital region categories.
Background: COVID-19 is known to be associated with acute myocardial infarction (MI).
Objectives: The purpose of this study was to evaluate the outcomes of 30-day readmissions for MI among survivors of COVID-19 hospitalization.
Methods And Results: We used the U.
Background: The initiation of coronary artery calcium (CAC) is an important physiologic milestone associated with increased cardiovascular disease risk. However, traditional risk factors (RF) do not perform well for predicting incident CAC among the 54 million older U.S.
View Article and Find Full Text PDFBackground: Recent evidence has shown that reproductive factors are associated with an increased risk of heart failure with preserved ejection fraction in women. However, the pathogenic pathways underlying this relationship are unclear. Subclinical myocardial fibrosis has been found to be a common pathway in a large proportion of patients with heart failure with preserved ejection fraction.
View Article and Find Full Text PDFBackground: Persons with COVID-19 infection have an increased risk of pregnancy-related complications. However, data on acute cardiovascular (CV) complications during delivery admissions remain limited.
Objectives: The purpose of this study was to determine whether pregnant individuals with COVID-19 have an increased risk of acute peripartum CV complications during their delivery admission.
Dysanapsis Genetic Risk Predicts Lung Function Across the Lifespan.
Am J Respir Crit Care Med
December 2024
Dysanapsis refers to a mismatch between airway tree caliber and lung size arising early in life. Dysanapsis assessed by computed tomography (CT) is evident by early adulthood and associated with chronic obstructive pulmonary disease (COPD) risk later in life. By examining the genetic factors associated with CT-assessed dysanapsis, we aimed to elucidate its molecular underpinnings and physiological significance across the lifespan.
View Article and Find Full Text PDFAim: To investigate the association between endogenous sex hormone levels and history of tooth loss related to periodontitis in healthy middle-aged to older men and post-menopausal women.
Methods: This cross-sectional study included 5649 participants aged 45-84 (mean age, 63 ± 10 years) from the Multi-Ethnic Study of Atherosclerosis cohort who had sex hormone levels measured and answered a questionnaire regarding perceived periodontal status at exam 1. Multivariable logistic regression was used to examine the association of sex hormones (exposure) with history of tooth loss (outcome), stratified by sex.
Background And Aims: Calcific aortic valve disease is associated with increased thrombin formation, platelet activation, decreased fibrinolysis, and subclinical brain infarcts. We examined the long-term association of aortic valve calcification (AVC) with newly diagnosed dementia and incident stroke in the Multi-Ethnic Study of Atherosclerosis (MESA).
Methods: AVC was measured using non-contrast cardiac CT at Visit 1.
Article Synopsis
- The spectrum of cardiorenal and metabolic diseases includes various disorders like obesity, type 2 diabetes, chronic kidney disease, and heart failure, often co-existing in the same patient due to shared physiological pathways.
- Recent trials have shown that treatments can benefit multiple conditions simultaneously, highlighting a need for updated clinical guidance.
- An international task force of specialists has created the DCRM 2.0 Practice Recommendations, which consist of 22 graphics to help clinicians manage these complex conditions effectively, aiming to enhance patient health and outcomes.
Forecasting the Burden of Cardiovascular Disease and Stroke in the United States Through 2050-Prevalence of Risk Factors and Disease: A Presidential Advisory From the American Heart Association.
Circulation
July 2024
Article Synopsis
- Cardiovascular disease and stroke are becoming more common and costly, with projections indicating significant increases in related risk factors like hypertension, diabetes, and obesity up to 2050.
- Data from national health surveys suggests that while some issues like poor diet and smoking may improve, overall cardiovascular disease prevalence will still rise, significantly impacting millions of adults.
- There is a pressing need for targeted public health interventions to manage and potentially reverse these concerning trends, especially among vulnerable racial and ethnic groups.