Publications by authors named "Eriko Tsuboi"
Article Synopsis
- Limb reduction has a long history in tetrapods, with emus being a key model for studying genetic mechanisms behind this phenomenon.
- The study reveals that the absence of distal muscles leads to skeletal shortening, fusion, and variability in wing structure due to immobilization.
- Analysis shows that muscle progenitor cells with distinct signatures contribute to this process, and their death is linked to reduced mechanical loading, impacting the wing's morphology during development.
Background: The serum level of eosinophil-derived neurotoxin (EDN), a protein present in eosinophil granules, correlates with the severity of childhood asthma. However, the relationship between the serum EDN level and the severity of adult asthma has not been sufficiently investigated.
Objective: This study aimed to elucidate the correlation between the serum EDN level and markers of severity in adult asthma.
Background: Inhaled corticosteroids enhance airway epithelial barrier integrity. However, the mechanism by which they accomplish this is unclear. Therefore, we investigated steroid-inducible genes and signaling pathways that were involved in enhancing airway epithelial barrier integrity.
View Article and Find Full Text PDFBackground: Allergic sensitization is a key step in the pathogenesis of asthma. However, little is known about the molecules that are critical regulators for establishing allergic sensitization of the airway. Thus, we conducted global gene expression profiling to identify candidate genes and signaling pathways involved in house dust mite (HDM)-induced allergic sensitization in the murine airway.
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