Coexistence of bone and vascular disturbances in patients with endogenous glucocorticoid excess.

Purpose: Bone and vascular diseases are considered to share pathogenic mechanisms. Excess glucocorticoids, key regulators of cardiovascular and metabolic homeostasis, may promote both diseases simultaneously. We used endogenous Cushing's syndrome (CS) to investigate whether glucocorticoid excess underlies coexisting bone and vascular diseases.

Machine learning-based models for predicting clinical outcomes after surgery in unilateral primary aldosteronism.

Unilateral subtype of primary aldosteronism (PA) is a common surgically curable form of endocrine hypertension. However, more than half of the patients with PA who undergo unilateral adrenalectomy suffer from persistent hypertension, which may discourage those with PA from undergoing adrenalectomy even when appropriate. The aim of this retrospective cross-sectional study was to develop machine learning-based models for predicting postoperative hypertensive remission using preoperative predictors that are readily available in routine clinical practice.

Protective Role of DHEAS in Age-related Changes in Bone Mass and Fracture Risk.

Purpose: Dehydroepiandrosterone sulfate (DHEAS) from the adrenal cortex substantially decreases with age, which may accelerate osteoporosis. However, the association of DHEAS with bone mineral density (BMD) and fracture is inconclusive. We conducted a Mendelian randomization (MR) analysis to investigate the role of DHEAS in age-related changes in BMD and fracture risk.

Necessity of Utilizing Physiological Glucocorticoids for Managing Familial Mediterranean Fever.

BACKGROUND Familial Mediterranean fever is an auto-inflammatory disease caused by pyrin mutations. Glucocorticoids inhibit the production and secretion of inflammatory cytokines, including IL-6 and IL-1ß, from inflammatory cells and suppress the activation of nuclear factor-kappaB in the nucleus. However, the functions of physiological glucocorticoids in the disease remain unknown.

Brown adipose activation and reversible beige coloration in adipose tissue with multiple accumulations of F-fluorodeoxyglucose in sporadic paraganglioma: A case report.

In pheochromocytoma/paraganglioma, nontumorous high F-fluorodeoxyglucose accumulations are observed in both beige and brown adipose tissues. Recognizing this feature of F-fluorodeoxyglucose accumulation can help physicians make precise diagnoses and help them avoid the pitfalls of a false-positive F-fluorodeoxyglucose positron emission tomography result, preventing unnecessary interventions.

Exchange interaction of 5,5'-(m- and p-phenylene)bis(10-phenyl-5,10-dihydrophenazine) dications and related analogues.

[structures: see text] 5,5'-(m-Phenylene)bis[(10-aryl-5,10-dihydrophenazine) dications, 3a2+ and 3b2+, and their p-analogues 4a2+ and 4b2+, were prepared, and their exchange interaction was investigated. The EPR spectra of these dications at 123 K in a butyronitrile matrix showed the population of a triplet state. The temperature dependence of the EPR signal intensity (absolute value(delta m(s)) = 2) showed that these dications had singlet ground states with deltaE(ST)/k(B) = -27 to -21 K for the m-isomer 3(2+) and with deltaE(ST)/k(B) = -10 to -8 K for the p-isomer 4(2+).

Facile synthesis of 5,10-diaryl-5,10-dihydrophenazines and application to EL devices.

[structures: see text] An efficient method for the synthesis of 5,10-diaryldihydrophenazine was developed using a recently developed Pd(0)-mediated cross-coupling reaction. The products 1k and 3c showed excellent properties as hole injection materials in electroluminescent (EL) devices.