Publications by authors named "Eriko Tabata"
Article Synopsis
- Small amounts of the EGFR T790M mutation (micro-T790M) can be identified in tissue samples through droplet digital PCR, which might serve as a predictive factor for the effectiveness of EGFR-tyrosine kinase inhibitors (TKIs).
- The study aimed to clarify the predictive value of micro-T790M for three generations of EGFR-TKIs (1G, 2G, and 3G) by excluding potential false positives in previous analyses.
- Results showed that micro-T790M-positive patients had a significantly longer time to treatment failure (TTF) with 2G and 3G EGFR-TKIs compared to those receiving 1G, indicating that micro-T790M could
Article Synopsis
- A phase 2 trial tested the combination of docetaxel and ramucirumab with pegylated-granulocyte-colony stimulating factor (PEG-G-CSF) in elderly, chemo-naive patients (aged 75+) with advanced non-small cell lung cancer (NSCLC) to reduce the risk of febrile neutropenia (FN).
- Out of 54 enrolled patients, the overall response rate (ORR) was 38.9% with a substantial disease control rate of 79.6%, while the median progression-free survival and overall survival were 5.2 and 12.7 months, respectively.
- The treatment demonstrated a favorable safety profile, with a low occurrence of FN (
Purpose: We evaluated plasma cell-free DNA (cfDNA) and tissue-based sequencing concordance for comprehensive oncogenic driver detection in non-small cell lung cancer (NSCLC) using a large-scale prospective screening cohort (LC-SCRUM-Liquid).
Experimental Design: Blood samples were prospectively collected within 4 weeks of corresponding tumor tissue sampling from patients with advanced NSCLC to investigate plasma cfDNA sequencing concordance for alterations in 8 oncogenes (EGFR, KRAS, BRAF, HER2, MET, ALK, RET, and ROS1) compared with tissue-based next-generation targeted sequencing.
Results: Paired blood and tissue samples were obtained in 1,062/1,112 enrolled patients with NSCLC.
We report a case of acute respiratory distress syndrome caused by uropathogenic Escherichia coli induced sepsis and treated successfully. A 56-year-old women admitted for high-fever, dyspnea, and disturbance of consciousness on September 11, 2006, was found in chest computed tomography (CT) on admission to have diffuse infiltration with bilateral pleural effusion. Abdominal CT on admission showed left hydronephrosis complicated with ureteral stones.
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