Publications by authors named "Erika U Lima"
Introduction: Forkhead box E1 () is a transcription factor with a crucial role in thyroid morphogenesis and differentiation. Promoter hypermethylation downregulates expression in different tumor types; nevertheless, its expression and relationship with methylation status in differentiated thyroid cancer (DTC) remain unclear.
Methods: A total of 33 pairs of matched samples of PTC tumors and non-tumors were included.
Background: The inactivation of the tumor-suppressor homeodomain-only protein X (HOPX) usually involves promoter methylation in several cancer types. This study aimed to investigate the HOPX-β mRNA expression and promoter methylation and their clinical relevance in differentiated thyroid cancer (DTC).
Patients And Methods: Clinicopathological data and paraffin-embedded thyroid tumor tissues from 21 patients with DTC and 6 with benign tumors (T) and their non-tumor parenchyma (NT) were investigated.
Objective: The p.V600E BRAF and RAS mutations are found in 30-80% of differentiated thyroid carcinoma (DTC). BRAF mutation has been associated with poor prognosis.
View Article and Find Full Text PDFNew mutation in the PTEN gene in a Brazilian patient with Cowden's syndrome.
Arq Bras Endocrinol Metabol
November 2012
Article Synopsis
- Cowden syndrome involves hamartomatous polyps, trichilemmomas, a heightened risk of tumors, and is linked to mutations in the PTEN gene.
- A study was conducted on a 49-year-old woman with trichilemmoma and a history of breast cancer and thyroid issues to investigate PTEN mutations.
- A novel germline mutation in PTEN was discovered, alongside evidence of somatic loss of the wild-type PTEN allele in her breast and thyroid tumors.
Background: Some studies have demonstrated a correlation between the presence of a BRAF mutation and aggressive characteristics, including lymph node metastasis in papillary thyroid carcinoma (PTC). Prophylactic central neck dissection (CND) has been proposed for treatment of PTC. Given the potential complications of CND, we undertook a prospective study to determine the correlation between the BRAF mutation and lymph node metastasis.
View Article and Find Full Text PDFBackground: Cytotoxic T lymphocyte-associated factor 4 (CTLA-4) functions as a negative regulator of T cell-mediated immune response. Molecular changes associated to CTLA-4 gene polymorphisms could reduce its ability to suppress and control lymphocyte proliferation.
Aims: To evaluate the frequency of CTLA-4 gene polymorphisms in chronic hepatitis C virus (HCV) infected patients and correlate to clinical and histological findings.