Publications by authors named "Erika Truffer"
Article Synopsis
- Fgf8 is crucial for the proper development of the urogenital tract, particularly for the formation of the cranial mesonephric tubules and associated structures like the epididymis and vas deferens.
- In experiments with Fgf8-deficient mice, significant developmental issues were observed, such as the absence of the cranial mesonephric tubules and premature degeneration of the cranial Wolffian duct.
- FGF8 acts upstream of Lhx1 in nephron formation, and its deficiency leads to impaired Lhx1 expression, highlighting the important signaling pathways involved in the development of male reproductive tract ducts.
Neurofibromatosis type 1 (NF1) is one of the most common human genetic diseases affecting the nervous system and predisposes individuals to cancer, including peripheral nerve sheath tumors (PNSTs) and astrocytomas. Modifiers in the genetic background affect the severity of the disease and we have previously mapped two modifier loci, Nstr1 and Nstr2, that influence resistance to PNSTs in the Nf1-/+;Trp53-/+cis mouse model of NF1. We report here the analysis of Nstr1 in isolation from other epistatic loci using a chromosome substitution strain, and further show that a modifier locus (or loci) on chromosome 19 influences resistance to both PNSTs and astrocytomas.
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