[Clinical characteristics of 5 hospitalized 3,4-methylenedioxypyrovalerone (MDPV) users].

A new illegal psychotropic substance appeared in Hungary during the first months of 2011. Acutely hospitalized patients with psychosis disclosed using a new type of designer drug, previously unknown to clinicians. As the new drug became better known, the cases with acute intoxication were often also transported to toxicology departments.

Designer drugs in psychiatric practice - a review of the literature and the recent situation in Hungary.

In recent years service providers experienced a new phenomenon in the drug markets of Hungary: the dramatically increasing sale and use of designer drugs. In psychiatric practice, the first sign of this new trend was the increasing number of hospitalized patients with acute psychosis using a new type of designer drug: MDPV (3,4-Methylenedioxypyrovalerone). The range of designer drugs available is wider than ever before.

Emotion appraisal and the tryptophan hydroxylase 2 (TPH2) gene.

The purpose of this study was to investigate the association between the G-703T polymorphism of the tryptophan hydroxylase 2 (TPH2) gene (rs4570625) and emotion appraisal in healthy volunteers. Participants were asked to recall a situation characterized by a strong emotion and to rate appraisal processes: novelty/expectation, pleasantness, goal-conduciveness, fairness, responsibility/causation, coping ability, morality, and relationship to self-concept. Results revealed that in the case of fear- and sadness-related autobiographical memories, participants with the GG genotype achieved higher appraisal scores for goal-conduciveness and lower scores for coping ability compared with participants with the TT genotype.

Delusion proneness and emotion appraisal in individuals with high psychosis vulnerability.

Unlabelled: Evidence suggests that emotional processes play an important role in the development of delusions. The aim of the present study was to investigate emotion appraisal in individuals with high and low psychosis proneness. We compared 30 individuals who experienced a transient psychotic episode followed by a complete remission with 30 healthy control volunteers.

Anomalous subjective experience and psychosis risk in young depressed patients.

Background: Help-seeking young people often display depressive symptoms. In some patients, these symptoms may co-exist with clinically high-risk mental states for psychosis. The aim of this study was to determine differences in subjective experience and social perception in young depressed patients with and without psychosis risk.

Facial expression recognition in depressed subjects: the impact of intensity level and arousal dimension.

The goal was to investigate whether patients with depression perform more poorly in overall emotion perception tasks compared with controls and whether this difference varies as a function of emotional intensity and arousal, with a perceptual bias toward high arousal emotions. Data were collected from 23 depressed and 23 control subjects, matched for gender, age, and education. Basic emotions were presented at 5 intensity levels ranging from 20% to 100%.

Emotion-related brain regions.

Converging data from human functional imaging in healthy subjects, neuropsychological studies of brain-damaged patients, and non-human neurophysiology indicate that emotional processing is linked to anatomically distinct and well-defined brain regions. A main characteristic of emotion-related brain regions (orbitofrontal cortex, anterior cingulated cortex, amygdala, insula) is their reciprocal anatomical connectivity with each other as well as with neuromodulatory systems (e.g.

Emotion appraisal is modulated by the genetic polymorphism of the serotonin transporter.

We investigated the relationship between the genetic polymorphism of the promoter of the serotonin transporter gene (SLC64A) and emotion appraisal profiles for fear, sadness, and joy in 114 healthy volunteers. Results revealed that carriers of the s-allele achieved higher scores than non-carriers for unpleasantness and goal-hindrance but scored lower for coping ability in the case of fear and sadness. There were no such differences in the case of joy.

[Neuropsychiatric symptoms caused by mefloquine (report of several cases)].

Introduction: The number of Hungarian citizens travelling to countries infected with malaria is increasing year by year. Mefloquine is the most effective medicine in the prophylaxis and treatment of malaria. However, neuropsychiatric side-effects can more often be seen with the use of mefloquine compared to other anti-malaria drugs.