Publications by authors named "Erika Maka"

Purpose: In PAX6 syndrome, it is still not clear, whether prenatally, parallel to the iris tissue developmental anomaly, there is neural ectodermal, neural crest, or mesodermal cell deposition at the corneal endothelium, affecting endothelial structure and function. In addition, because of the postnatal corneal inflammation and commonly appearing secondary glaucoma, progressive endothelial changes are expected. Our purpose was to study the corneal endothelium in subjects with PAX6 aniridia, using in vivo confocal laser scanning microscopy.

View Article and Find Full Text PDF
Article Synopsis
  • The study investigates the effectiveness of using a laryngeal mask airway (LMA) compared to an endotracheal tube (ETT) for airway management in preterm infants undergoing laser treatment for retinopathy of prematurity.
  • Results showed that only 8% of infants using LMA required postoperative mechanical ventilation (MV), compared to 74% using ETT, indicating a significant reduction in MV needs with LMA.
  • The findings suggest that using LMA is a safer and more effective alternative to ETT, as evidenced by lower odds of needing MV and potentially reducing associated risks during recovery.
View Article and Find Full Text PDF

Purpose: During life up to 70% of aniridia subjects develop aniridia-associated keratopathy (AAK). AAK is characterized by limbal stem cell insufficiency, impaired corneal epithelial cell differentiation and abnormal cell adhesion, which leads to centripetal spreading vascularization, conjunctivalization, and thickening of the cornea. Our aim was to examine the subbasal nerve plexus and central corneal stromal microstructure in subjects with congenital aniridia, using confocal laser scanning microscopy CLSM.

View Article and Find Full Text PDF

Cystinosis is a low-prevalence lysosomal storage disease. The pathomechanism involves abnormal functioning of the cystinosine lysosomal cystine transporter (CTNS), causing intraliposomal accumulation of the amino acid cysteine disulfide, which crystallizes and deposits in several parts of the body. The most common ophthalmic complication of cystinosis is the deposition of "gold dust" cystine crystals on the cornea, which already occurs in infancy and leads to severe photosensitivity and dry eyes as it gradually progresses with age.

View Article and Find Full Text PDF

Introduction: Aniridia is a rare congenital panocular disease associated with varying degrees of visual acuity impairment.

Objective: To assess the experiences of congenital aniridia patients in Hungary, with visual impairment using a questionnaire developed by the ANIRIDIA-NET.

Patients And Method: Patients completed the Hungarian version of the 20-item ANIRIDIA-NET questionnaire with our assistance.

View Article and Find Full Text PDF
Article Synopsis
  • Congenital aniridia is a rare eye condition that affects almost all structures of the eye, often leading to poor vision, with various associated problems like keratopathy and glaucoma.
  • This study examined 65 eyes from 33 patients in Hungary, classifying corneal abnormalities using multiple staging systems including Mackman, Mayer, López-García, and Lagali.
  • The findings suggest using Lagali's staging due to its user-friendly format and effectiveness in monitoring disease progression and treatment planning.
View Article and Find Full Text PDF

Introduction: Congenital aniridia is a rare disease, characterised by the complete or partial absence of the iris, but lesions may be present in all structures of the eye.

Objective: To determine the prevalence of ocular diseases in congenital aniridia by analyzing patients from a Hungarian centre.

Patients And Methods: Patients at the Department of Ophthalmology of Semmelweis University, examined between October 2005 and May 2022, have been included.

View Article and Find Full Text PDF

Cystinosis is a rare lysosomal storage disease affecting amino acid metabolism, characterized by the accumulation and crystallization of cystine in various tissues, primarily in the eye and kidney. The major ophthalmic symptom is photophobia, which is related to the corneal deposition of cystine crystals. The light sensitivity significantly impairs the quality of life of the affected patients, thus, effective ophthalmic treatment to reduce the crystal density is very importance.

View Article and Find Full Text PDF

Beta-tubulin 4B isotype is one of the subunits of microtubules encoded by TUBB4B gene on chromosome 9, which is responsible for the maintenance of microtubule stability. In humans, mutations in microtubule-encoding genes have been associated with several tubulinopathies with very heterogeneous symptoms. So far, only two missense mutations in TUBB4B gene have been found to have pathological implications in this disorder.

View Article and Find Full Text PDF

Introduction: Advanced intraocular retinoblastoma can be cured by enucleation, but spread of retinoblastoma cells beyond the natural limits of the eye is related to a high mortality. Adjuvant therapy after enucleation has been shown to prevent metastasis in children with risk factors for extraocular retinoblastoma. However, histological criteria and adjuvant treatment regimens vary and there is no unifying consensus on the optimal choice of treatment.

View Article and Find Full Text PDF

Összefoglaló. Az Axenfeld-Rieger-szindróma ritka betegség. A közlemény bemutatja a klinikai megjelenési formáit, a diagnosztikus és terápiás lehetőségeket.

View Article and Find Full Text PDF

Background: The travel distance from home to a treatment centre, which may impact the stage at diagnosis, has not been investigated for retinoblastoma, the most common childhood eye cancer. We aimed to investigate the travel burden and its impact on clinical presentation in a large sample of patients with retinoblastoma from Africa and Europe.

Methods: A cross-sectional analysis including 518 treatment-naïve patients with retinoblastoma residing in 40 European countries and 1024 treatment-naïve patients with retinoblastoma residing in 43 African countries.

View Article and Find Full Text PDF

RNA modifications play a fundamental role in cellular function. Pseudouridylation, the most abundant RNA modification, is catalyzed by the H/ACA small ribonucleoprotein (snoRNP) complex that shares four core proteins, dyskerin (DKC1), NOP10, NHP2, and GAR1. Mutations in , , or cause dyskeratosis congenita (DC), a disorder characterized by telomere attrition.

View Article and Find Full Text PDF

Importance: Early diagnosis of retinoblastoma, the most common intraocular cancer, can save both a child's life and vision. However, anecdotal evidence suggests that many children across the world are diagnosed late. To our knowledge, the clinical presentation of retinoblastoma has never been assessed on a global scale.

View Article and Find Full Text PDF

Background: Presence of corneal cystine crystals is the main ocular manifestation of cystinosis, although controversial findings concerning the corneal layer with the highest density have been reported. The aim of this study was the analysis of the characteristics of crystal arrangement in different corneal layers and the assessment of corneal morphological changes with age.

Methods: A cross sectional study was carried out in three children and three adults who had nephropathic cystinosis and corneal cystine depositions.

View Article and Find Full Text PDF

Purpose: To assess the validity of wide-field digital imaging (WFDI) and telemedicine-based screening compared with examination by binocular indirect ophthalmoscopy (BIO) and to present some of the results from the first five years of telemedicine-based screening in the Premature Eye Rescue Program in Hungary.

Methods: We performed a retrospective analysis in two periods that aimed to assess (a) the validity of retinal digital imaging and (b) routine bedside screening. The validity was assessed in two neonatal intensive care units (NICUs), one in the First Department of Paediatrics and the other in the Second Department of Obstetrics and Gynaecology, Semmelweis University.

View Article and Find Full Text PDF
Article Synopsis
  • Idiopathic strabismus sursoadductorius involves an overactive inferior oblique muscle, causing eye elevation, headaches, pain, double vision, and unusual head positions.
  • A study between 2012-2017 treated 53 patients with a transposition of the inferior oblique muscle, evaluating outcomes at multiple time points post-surgery.
  • Results indicated significant improvement in vertical deviation and stable visual acuity, with most patients achieving acceptable binocular vision and low rates of complications.
View Article and Find Full Text PDF

Purpose: To analyse current clinicopathological enucleation indications in a large third-referral centre in a developed country (Hungary) over a period of 12 years.

Methods: Retrospective review was performed on 547 enucleated eyes of 543 patients (48.6% males, age 52.

View Article and Find Full Text PDF

Purpose: To investigate the differences in biometry data of eyes with unilateral congenital cataract and the contralateral normal eyes in pediatric patients.

Setting: Pediatric Ophthalmology Division, Ophthalmology Department, Semmelweis University in Budapest, Hungary.

Design: Retrospective case series.

View Article and Find Full Text PDF

Background And Aim: Peter Cerny Ambulance Service - Premature Eye Rescue Program (PCA-PERP) uses digital retinal imaging (DRI) with remote interpretation in bedside ROP screening, which has advantages over binocular indirect ophthalmoscopy (BIO) in screening of premature newborns. We aimed to demonstrate that PCA-PERP provides good value for the money and to model the cost ramifications of a similar newly launched system.

Methods: As DRI was demonstrated to have high diagnostic performance, only the costs of bedside DRI-based screening were compared to those of traditional transport and BIO-based screening (cost-minimization analysis).

View Article and Find Full Text PDF

Introduction: Retinopathy of prematurity is a leading cause of childhood blindness around the world.

Aim: The Department of Ophthalmology at the Semmelweis University and the Peter Cerny Neonatal Emergency and Ambulance Service started an innovative Premature Eye Rescue Program to reduce the non-essential transport of premature babies suffering from retinopathy of prematurity.

Method: During the first 5 years 186 eyes of 93 premature babies were treated at the bedside with stage 3 retinopathy of prematurity in the primary hospitals.

View Article and Find Full Text PDF

The most frequent form of hereditary blindness, autosomal dominant optic atrophy (ADOA), is caused by the mutation of the mitochondrial protein Opa1 and the ensuing degeneration of retinal ganglion cells. Previously we found that knockdown of OPA1 enhanced mitochondrial Ca(2+) uptake (Fülöp et al., 2011).

View Article and Find Full Text PDF

Background: The pathogenicity of the NPHS2 homozygous p.R229Q variant in steroid-resistant nephrotic syndrome (SRNS) is doubtful. While it has been reported in unaffected controls, it is enriched in patients with SRNS, suggesting pathogenicity.

View Article and Find Full Text PDF

Purpose: To measure the orbital volume in adult patients with unilateral eye movement abnormalities originating in childhood.

Methods: Cone-beam computed tomography was performed in 2 patients with eye movement abnormalities. A 28-year-old woman was treated because of right divergent squint originating at 8 years of age after penetrating corneal trauma.

View Article and Find Full Text PDF

A PHP Error was encountered

Severity: Warning

Message: fopen(/var/lib/php/sessions/ci_sessiono1p3rvbpa7d1d9jj43v57141cn8acfjk): Failed to open stream: No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 177

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)

Filename: Session/Session.php

Line Number: 137

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once