Publications by authors named "Erik van Exel"
Background: Neuropathological studies supported by experimental animal studies show that the constituents of the innate immunity are intimately involved in the early steps of the pathological cascade of Alzheimer's disease (AD).
Objectives: To show the evidence that constituents of the innate immunity contribute to the etiology of late-onset AD.
Methods: Evaluation of the relationship between the constituents of the innate immunity and genetic risk factors for late-onset AD.
Article Synopsis
- Oskar Fischer first suggested that senile plaques in Alzheimer's disease (AD) might trigger inflammation, leading to abnormal neuron responses.
- The study aims to establish that inflammation is not just a late occurrence but an early event in the development of AD.
- Findings indicate that inflammation is present in the brains of patients at early AD stages and that genetic factors related to inflammation are linked to increased risk of late-onset AD.