Evolution of methodology and reporting of emergency medicine quantitative research over a 20-year period.

Objective: We aimed to determine trends over time in article origin, and article and methodology characteristics.

Method: We examined original research articles published every fifth year over a 20-year period (1997-2017) in six emergency medicine (EM) journals (). Explicit data extraction of 21 article characteristics was undertaken.

Patient perceptions of participation in emergency medicine research projects.

Objective: To determine if ED research reflects patient expectations.

Method: A cross-sectional ED patient survey.

Results: Three hundred and nine (98.

Risk variables associated with abnormal calcium, magnesium and phosphate levels among emergency department patients.

Objective: The utility of calcium, magnesium and phosphate measurement in the ED is limited. We aimed to determine clinical risk variables for abnormal levels of these electrolytes in order to inform the development of an ordering guideline.

Methods: We performed a retrospective, observational study of patients who presented to a tertiary referral ED between January and June 2017.

Determination of the best early warning scores to predict clinical outcomes of patients in the emergency department.

Objective: Early warning scores (EWS) are used to predict patient outcomes. We aimed to determine which of 13 EWS, based largely on emergency department (ED) vital sign data, best predict important clinical outcomes.

Method: We undertook a prospective cohort study in a metropolitan, tertiary-referral ED in Melbourne, Australia (February-April 2018).

Utility of calcium, magnesium and phosphate testing in the emergency department.

Objective: To determine how frequently calcium (Ca), magnesium (Mg) and phosphate (PO ) tests change ED patient management.

Methods: We undertook a retrospective observational study in an Australian tertiary referral ED. We enrolled adult patients (aged ≥18 years) who presented between 1 January and 30 June 2017 and who had a serum Ca, Mg or PO test ordered and completed during their ED stay.

The Differential Binding of Antipsychotic Drugs to the ABC Transporter P-Glycoprotein Predicts Cannabinoid-Antipsychotic Drug Interactions.

Cannabis use increases rates of psychotic relapse and treatment failure in schizophrenia patients. Clinical studies suggest that cannabis use reduces the efficacy of antipsychotic drugs, but there has been no direct demonstration of this in a controlled study. The present study demonstrates that exposure to the principal phytocannabinoid, Δ-tetrahydrocannabinol (THC), reverses the neurobehavioral effects of the antipsychotic drug risperidone in mice.