Therapeutic potential of cannabinoids in neurodegenerative disorders: a selective review.

The endocannabinoid system (ECS) is now recognised as an important modulator of various central nervous system processes. More recently, an increasing body of evidence has accumulated to suggest antioxidant, anti-inflammatory and neuroprotective roles of ECS. In this review we discuss the role and therapeutic potential of ECS in neurodegenerative disorders such as Alzheimer's disease (AD), Parkinson's disease, multiple sclerosis, Huntington's disease, Tourette's syndrome, brain ischemia and amyotrophic lateral sclerosis (ALS).

A comparison of the effects of Snoezelen and reminiscence therapy on the agitated behaviour of patients with dementia.

Background: Behavioural disturbance, such as agitation, is a common feature of dementia, and causes significant problems and distress for carers. Snoezelen is increasingly used with people who have dementia, but there is limited evidence of its efficacy.

Objective: This crossover randomised controlled study aimed to evaluate the effect of Snoezelen on the mood and behaviour of patients with dementia, in comparison to the effect of an established and accepted intervention, reminiscence therapy.

The second Leicester survey of memory clinics in the British Isles.

Background: The number of memory clinics in the British Isles has increased since our first survey in 1993.

Objectives: The aim of this survey was to determine the memory clinics' characteristics and functions, and to compare these with the findings of our previous survey.

Methods: An expanded version of the 1993 questionnaire was sent to 102 possible memory clinics, identified by various means.